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NCT05446272 · ClinicalTrials.gov registry record · NA

The Diaphragmatic Initiated Ventilatory Assist (DIVA) Trial

A NA study of Bronchopulmonary Dysplasia and Death, sponsored by University of Pennsylvania.

Recruiting
Registry status
NA
Development phase
478
Enrollment target
20
Study locations

NCT05446272 is a NA study of Bronchopulmonary Dysplasia and Death that is actively recruiting participants, run by University of Pennsylvania. The registered enrollment target is 478 participants, above the 220-participant average among 29 other Bronchopulmonary Dysplasia trials with a reported enrollment target (117% higher). The trial reports 20 study locations across 14 states.

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The verdict

NCT05446272, a NA study of Bronchopulmonary Dysplasia and Death, is actively recruiting participants, sponsored by University of Pennsylvania.

RECRUITING
Registry status
NA
Development phase
478 participants
Enrollment target
20
Study locations

Study Summary

DIVA is a pragmatic randomized clinical trial (RCT) to determine: among (P) preterm infants born 23 0/7-28 6/7 weeks gestation undergoing extubation from mechanical ventilation, whether (I) Non-invasive neurally adjusted ventilatory assist (NIV-NAVA) (C) compared with Non-synchronized nasal intermittent positive pressure ventilation (NS-NIPPV), will reduce the incidence of (O) extubation failure within (T) 5 days (120 hours) of extubation.

Conditions Studied

Bronchopulmonary Dysplasia Death Extubation Failure

Interventions

  • DEVICE NIV-NAVA
  • DEVICE NS-NIPPV

Study Locations (20)

California

  • Loma Linda University - Loma Linda
  • Sharp Mary Birch - San Diego

Florida

  • Joe DiMaggio Children's Hospital - Hollywood
  • AdventHealth - Orlando

Missouri

  • Children's Mercy Hospital - Kansas City
  • Washington University in St.Louis - St Louis

North Carolina

  • Levine Children's Hospital - Charlotte
  • Atrial Health Brenner Children's Hospital( Wake Forest) - Winston-Salem

Utah

  • Intermountain Medical Center - Murray
  • Utah Valley Hospital - Provo

Other

  • Mt Sinai Hospital - Toronto
  • BC Children's and Women's Hospital - Vancouver

Arkansas

  • Arkansas Children's Hospital - Little Rock

Indiana

  • Peyton Manning Children's Hospital - Indianapolis

Trial Details

FieldValue
Enrollment Target 478 participants
Start Date 2022-08-03
Est. Completion 2027-03-31
Phase NA

Sponsor

University of Pennsylvania

1,423 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05446272

The ClinicalTrials.gov registry entry for NCT05446272 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 478 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 220-participant average among 29 other Bronchopulmonary Dysplasia trials with a reported enrollment target (117% higher). The listed sponsor is University of Pennsylvania, which has 1,423 total studies on file at ClinicalTrials.gov.

The record links to 3 conditions, with Bronchopulmonary Dysplasia appearing as the primary indexed condition, and to 2 interventions - of which NIV-NAVA is the first listed.

NCT05446272 reports 20 study locations spanning 14 distinct geographic areas - top geographies include California, Florida, Missouri.

Frequently Asked Questions

What is clinical trial NCT05446272 about?

NCT05446272 is a clinical study titled "The Diaphragmatic Initiated Ventilatory Assist (DIVA) Trial". DIVA is a pragmatic randomized clinical trial (RCT) to determine: among (P) preterm infants born 23 0/7-28 6/7 weeks gestation undergoing extubation from mechanical ventilation, whether (I) Non-invasive neurally adjusted ventilatory assist (NIV-NAVA) (C) compared with Non-synchronized nasal intermit...

What is the current status of trial NCT05446272?

This trial is currently recruiting. It is a NA study. The enrollment target is 478 participants. The study started on 2022-08-03. Estimated completion is 2027-03-31.

What conditions does trial NCT05446272 study?

This clinical trial studies the following conditions: Bronchopulmonary Dysplasia, Death, Extubation Failure.

What interventions are being tested in trial NCT05446272?

The interventions under investigation include: NIV-NAVA (DEVICE), NS-NIPPV (DEVICE).

Who is sponsoring clinical trial NCT05446272?

This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05446272 being conducted?

This trial has 20 study locations across Arkansas, California, Florida, Indiana, Kentucky. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.