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NCT06491823 · ClinicalTrials.gov registry record · NA
Speech Motor Learning and Retention (Aim 2)
A NA study of Speech, sponsored by Yale University.
- Recruiting
- Registry status
- NA
- Development phase
- 120
- Enrollment target
- 1
- Study location
NCT06491823: Recruiting NA study of Speech, sponsored by Yale University.
NCT06491823 is a NA study of Speech that is actively recruiting participants, run by Yale University. The registered enrollment target is 120 participants, below the 162-participant average among 9 other Speech trials with a reported enrollment target (26% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06491823, a NA study of Speech, is actively recruiting participants, sponsored by Yale University.
- RECRUITING
- Registry status
- NA
- Development phase
- 120 participants
- Enrollment target
- 1
- Study location
Study Summary
The overall goal of this research is to test a new model of speech motor learning, whose central hypothesis is that learning and retention are associated with plasticity not only in motor areas of the brain but in auditory and somatosensory regions as well. The strategy for the proposed research is to identify individual brain areas that contribute causally to retention by disrupting their activity with transcranial magnetic stimulation (TMS). Investigators will also use functional magnetic resonance imaging (fMRI) which will enable identification of circuit-level activity which predicts either learning or retention of new movements, and hence test the specific contributions of candidate sensory and motor zones. In other studies, investigators will record sensory and motor evoked potentials over the course of learning to determine the temporal order in which individual sensory and cortical motor regions contribute. The goal here is to identify brain areas in which learning-related plasticity occurs first and which among these areas predict subsequent learning.
Primary Outcome
Audapter software will be used to alter the first and second formant frequencies of the spoken words and this is played back to subjects through headphones. Subjects will be tested both with unaltered feedback and with abruptly introduced frequency shifts.The change in the first (F1) and second format frequency (F2) values will be assessed using Praat.
Conditions Studied
Interventions
- BEHAVIORAL Adaptation
- BEHAVIORAL Adaptation baseline
- DEVICE Motor evoked potentials
- DEVICE Auditory evoked potentials
- DEVICE Somatosensory evoked potentials
Study Locations (1)
Connecticut
- Yale Child Study Center - New Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2024-10-01 |
| Est. Completion | 2029-05-31 |
| Phase | NA |
What NCT06491823 shows while recruiting
NCT06491823 is an interventional study that assigns participants to a tested intervention. The registered 120 participants enrollment target is mid-sized for trials with a published cap, below the 162-participant average among 9 other Speech trials with a reported enrollment target (26% lower).
The record links to 1 condition, with Speech appearing as the primary indexed condition, and to 5 interventions - of which Adaptation is the first listed.
NCT06491823 reports a single indexed study location in Connecticut.
Frequently Asked Questions
What is clinical trial NCT06491823 about?
NCT06491823 is a clinical study titled "Speech Motor Learning and Retention (Aim 2)". The overall goal of this research is to test a new model of speech motor learning, whose central hypothesis is that learning and retention are associated with plasticity not only in motor areas of the brain but in auditory and somatosensory regions as well. The strategy for the proposed research is ...
What is the current status of trial NCT06491823?
This trial is currently recruiting. It is a NA study. The enrollment target is 120 participants. The study started on 2024-10-01. Estimated completion is 2029-05-31.
What conditions does trial NCT06491823 study?
This clinical trial studies the following conditions: Speech.
What interventions are being tested in trial NCT06491823?
The interventions under investigation include: Adaptation (BEHAVIORAL), Adaptation baseline (BEHAVIORAL), Motor evoked potentials (DEVICE), Auditory evoked potentials (DEVICE), Somatosensory evoked potentials (DEVICE).
Who is sponsoring clinical trial NCT06491823?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06491823 being conducted?
This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Speech
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06491823's enrollment target sits among peer trials
120 4th of 9 higher than 5 of 9 other Speech trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Speech trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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Speech Motor Learning and Retention (Aim 1)
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