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NCT06467305 · ClinicalTrials.gov registry record · NA
Speech Motor Learning and Retention (Aim 1)
A NA study of Speech, sponsored by Yale University.
- Recruiting
- Registry status
- NA
- Development phase
- 160
- Enrollment target
- 1
- Study location
NCT06467305: Recruiting NA study of Speech, sponsored by Yale University.
NCT06467305 is a NA study of Speech that is actively recruiting participants, run by Yale University. The registered enrollment target is 160 participants, roughly in line with the 158-participant average among 9 other Speech trials with a reported enrollment target. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06467305, a NA study of Speech, is actively recruiting participants, sponsored by Yale University.
- RECRUITING
- Registry status
- NA
- Development phase
- 160 participants
- Enrollment target
- 1
- Study location
Study Summary
The overall goal of this research is to test a new model of speech motor learning, whose central hypothesis is that learning and retention are associated with plasticity not only in motor areas of the brain but in auditory and somatosensory regions as well. The strategy for the proposed research is to identify individual brain areas that contribute causally to retention by disrupting their activity with transcranial magnetic stimulation (TMS). Investigators will also use functional magnetic resonance imaging (fMRI) which will enable identification of circuit-level activity which predicts either learning or retention of new movements, and hence test the specific contributions of candidate sensory and motor zones. In other studies, investigators will record sensory and motor evoked potentials over the course of learning to determine the temporal order in which individual sensory and cortical motor regions contribute. The goal here is to identify brain areas in which learning-related plasticity occurs first and which among these areas predict subsequent learning.
Primary Outcome
Audapter software will be used to alter the first and second formant frequencies of the spoken words and this is played back to subjects through headphones. Subjects will be tested both with unaltered feedback and with abruptly introduced frequency shifts.The change in the first (F1) and second format frequency (F2) values will be assessed using Praat.
Conditions Studied
Interventions
- DEVICE continuous theta-burst stimulation (cTBS)
- BEHAVIORAL Adaptation
Study Locations (1)
Connecticut
- Yale Child Study Center - New Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 160 participants |
| Start Date | 2024-10-01 |
| Est. Completion | 2029-05-31 |
| Phase | NA |
What NCT06467305 shows while recruiting
NCT06467305 is an interventional study that assigns participants to a tested intervention. The registered 160 participants enrollment target is mid-sized for trials with a published cap, roughly in line with the 158-participant average among 9 other Speech trials with a reported enrollment target.
The record links to 1 condition, with Speech appearing as the primary indexed condition, and to 2 interventions - of which continuous theta-burst stimulation (cTBS) is the first listed.
NCT06467305 reports a single indexed study location in Connecticut.
Frequently Asked Questions
What is clinical trial NCT06467305 about?
NCT06467305 is a clinical study titled "Speech Motor Learning and Retention (Aim 1)". The overall goal of this research is to test a new model of speech motor learning, whose central hypothesis is that learning and retention are associated with plasticity not only in motor areas of the brain but in auditory and somatosensory regions as well. The strategy for the proposed research is ...
What is the current status of trial NCT06467305?
This trial is currently recruiting. It is a NA study. The enrollment target is 160 participants. The study started on 2024-10-01. Estimated completion is 2029-05-31.
What conditions does trial NCT06467305 study?
This clinical trial studies the following conditions: Speech.
What interventions are being tested in trial NCT06467305?
The interventions under investigation include: continuous theta-burst stimulation (cTBS) (DEVICE), Adaptation (BEHAVIORAL).
Who is sponsoring clinical trial NCT06467305?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06467305 being conducted?
This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Speech
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06467305's enrollment target sits among peer trials
160 3rd of 9 higher than 7 of 9 other Speech trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Speech trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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Speech Motor Learning and Retention (Aim 2)
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