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NCT06449287 · ClinicalTrials.gov registry record · NA
Impact of Exogenous Ketones on Indices of Keto-Adaptation in Obese Subjects on Weight Reducing Diets.
A NA study of Weight Loss and Ketogenic Diet, sponsored by Ohio State University.
- Completed
- Registry status
- NA
- Development phase
- 37
- Enrollment target
- 1
- Study location
NCT06449287: Completed NA study of Weight Loss and Ketogenic Diet, sponsored by Ohio State University.
NCT06449287 is a NA study of Weight Loss and Ketogenic Diet that has completed, run by Ohio State University. The registered enrollment target is 37 participants, below the 1,501-participant average among 116 other Weight Loss trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06449287, a NA study of Weight Loss and Ketogenic Diet, has completed, sponsored by Ohio State University.
- COMPLETED
- Registry status
- NA
- Development phase
- 37 participants
- Enrollment target
- 1
- Study location
Study Summary
This project will be a three-group controlled 6-wk feeding study where all meals are prepared and provided to obese participants. All participants will be fed a 25% energy-restricted diet. Two diets will be very low in carbohydrate (i.e., ketogenic diets) designed to induce nutritional ketosis and fat loss. Another diet will be low in fat and saturated fat but contain the same total calories. Participants will be randomly assigned to a Ketone Supplement group who are provided an exogenous pre-formed source of beta-hydroxybutyrate (BOHB) or a Control group that only receives the standard ketogenic diet. Randomization will be stratified based on insulin resistance, sex, and body composition to ensure balanced group assignment. Because of timing of recruitment (i.e., after most of the ketogenic groups have already completed the study), the low-fat group will not be randomized. Outcome measurements will be made at various intervals over the 6-wk intervention.
Primary Outcome
Daily fasting glucose/ketones will be assessed using capillary finger stick lancing. A small drop of blood will be obtained once daily, while fasting, using enzymatic strips fitted for a handheld analyzer (KetoMojo). All the data will be stored in the device's internal memory.
Conditions Studied
Interventions
- BIOLOGICAL Blood Draw
- OTHER Diet
- BIOLOGICAL Ketone/Glucose Monitoring
- OTHER Body Composition
- BIOLOGICAL Urine Analysis
Study Locations (1)
Ohio
- The Ohio State University - Columbus
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 37 participants |
| Start Date | 2018-07-05 |
| Est. Completion | 2019-08-21 |
| Phase | NA |
What the finished NCT06449287 record still lists
NCT06449287 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 37 participants, a relatively small participant target, below the 1,501-participant average among 116 other Weight Loss trials with a reported enrollment target (98% lower).
The record links to 2 conditions, with Weight Loss appearing as the primary indexed condition, and to 5 interventions - of which Blood Draw is the first listed.
NCT06449287 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT06449287 about?
NCT06449287 is a clinical study titled "Impact of Exogenous Ketones on Indices of Keto-Adaptation in Obese Subjects on Weight Reducing Diets.". This project will be a three-group controlled 6-wk feeding study where all meals are prepared and provided to obese participants. All participants will be fed a 25% energy-restricted diet. Two diets will be very low in carbohydrate (i.e., ketogenic diets) designed to induce nutritional ketosis and f...
What is the current status of trial NCT06449287?
This trial is currently completed. It is a NA study. The enrollment target is 37 participants. The study started on 2018-07-05. Estimated completion is 2019-08-21.
What conditions does trial NCT06449287 study?
This clinical trial studies the following conditions: Weight Loss, Ketogenic Diet.
What interventions are being tested in trial NCT06449287?
The interventions under investigation include: Blood Draw (BIOLOGICAL), Diet (OTHER), Ketone/Glucose Monitoring (BIOLOGICAL), Body Composition (OTHER), Urine Analysis (BIOLOGICAL).
Who is sponsoring clinical trial NCT06449287?
This trial is sponsored by Ohio State University, which has 552 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06449287 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06449287's enrollment target sits among peer trials
37 93rd of 116 higher than 24 of 116 other Weight Loss trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Weight Loss trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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