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NCT06408181 · ClinicalTrials.gov registry record · Phase 3

APPLE: Aspirin to Prevent Pregnancy Loss and Preeclampsia

A Phase 3 study of Pre-Eclampsia and Pregnancy Loss, sponsored by University of Pennsylvania.

Recruiting
Registry status
Phase 3
Development phase
1,150
Enrollment target
1
Study location

NCT06408181 is a Phase 3 study of Pre-Eclampsia and Pregnancy Loss that is actively recruiting participants, run by University of Pennsylvania. The registered enrollment target is 1,150 participants, above the 364-participant average among 8 other Pre-Eclampsia trials with a reported enrollment target (216% higher). The trial reports 1 study location across 1 state.

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The verdict

NCT06408181, a Phase 3 study of Pre-Eclampsia and Pregnancy Loss, is actively recruiting participants, sponsored by University of Pennsylvania.

RECRUITING
Registry status
Phase 3
Development phase
1,150 participants
Enrollment target
1
Study location

Study Summary

The goal of this clinical trial is to investigate the effects of early initiation of double low-dose aspirin in pregnant women. The main questions it aims to answer are: Does this dose and timing of aspirin reduce the risk of pre-eclampsia compared to standard recommendations? Does this dose and timing of aspirin reduce the risk of pregnancy loss compared to standard recommendations? Participants will begin taking at no later than 6 weeks 6 days gestational age, either 162mg of aspirin through delivery or placebo until 12 weeks and then 81mg of aspirin through delivery.

Conditions Studied

Pre-Eclampsia Pregnancy Loss

Interventions

  • DRUG Aspirin 162 mg
  • DRUG Aspirin 81mg

Study Locations (1)

Pennsylvania

  • University of Pennsylvania - Philadelphia

Trial Details

FieldValue
Enrollment Target 1,150 participants
Start Date 2024-06-12
Est. Completion 2029-06
Phase Phase 3

Sponsor

University of Pennsylvania

1,423 total trials

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What the Registry Record Tells You About NCT06408181

The ClinicalTrials.gov registry entry for NCT06408181 describes a study currently listed as recruiting, categorized as Phase 3. The registered enrollment target is 1,150 participants, a figure that helps gauge the scale of data the investigators plan to collect, above the 364-participant average among 8 other Pre-Eclampsia trials with a reported enrollment target (216% higher). The listed sponsor is University of Pennsylvania, which has 1,423 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Pre-Eclampsia appearing as the primary indexed condition, and to 2 interventions - of which Aspirin 162 mg is the first listed.

NCT06408181 reports 1 study location spanning 1 distinct geographic area - top geographies include Pennsylvania.

Frequently Asked Questions

What is clinical trial NCT06408181 about?

NCT06408181 is a clinical study titled "APPLE: Aspirin to Prevent Pregnancy Loss and Preeclampsia". The goal of this clinical trial is to investigate the effects of early initiation of double low-dose aspirin in pregnant women. The main questions it aims to answer are: Does this dose and timing of aspirin reduce the risk of pre-eclampsia compared to standard recommendations? Does this dose and ti...

What is the current status of trial NCT06408181?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 1,150 participants. The study started on 2024-06-12. Estimated completion is 2029-06.

What conditions does trial NCT06408181 study?

This clinical trial studies the following conditions: Pre-Eclampsia, Pregnancy Loss.

What interventions are being tested in trial NCT06408181?

The interventions under investigation include: Aspirin 162 mg (DRUG), Aspirin 81mg (DRUG).

Who is sponsoring clinical trial NCT06408181?

This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06408181 being conducted?

This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.