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NCT06333990 · ClinicalTrials.gov registry record · Phase 3
Quetiapine to Reduce Post Concussive Syndrome After Mild Traumatic Brain Injury (mTBI)
A Phase 3 study of Mild Traumatic Brain Injury, sponsored by Foundation for Advancing Veterans' Health Research.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 146
- Enrollment target
- 2
- Study locations
NCT06333990: Recruiting Phase 3 study of Mild Traumatic Brain Injury, sponsored by Foundation for Advancing Veterans' Health Research.
NCT06333990 is a Phase 3 study of Mild Traumatic Brain Injury that is actively recruiting participants, run by Foundation for Advancing Veterans' Health Research. The registered enrollment target is 146 participants, below the 217-participant average among 43 other Mild Traumatic Brain Injury trials with a reported enrollment target (33% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06333990, a Phase 3 study of Mild Traumatic Brain Injury, is actively recruiting participants, sponsored by Foundation for Advancing Veterans' Health Research.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 146 participants
- Enrollment target
- 2
- Study locations
Study Summary
A two site, 2-arm, Phase III randomized pragmatic clinical trial evaluating the effectiveness of quetiapine monotherapy in comparison to Treatment As Usual (TAU) medication management for symptoms experienced by veterans receiving rehabilitation therapy for mild traumatic brain injury (mTBI) and comorbid symptoms of posttraumatic stress disorder (PTSD).
Primary Outcome
A 22- item, self-report measure of symptoms of postconcussive symptoms severity for the preceding 2 week period. Items are scored on a 5-point scale, and a total score is obtained by summing the 22 symptom items, with higher scores indicate greater symptom severity. The total scores range from 0 - 88.
Conditions Studied
Interventions
- DRUG TAU
- DRUG Quetiapine Fumarate
Study Locations (2)
New Mexico
- New Mexico VA Healthcare System - Albuquerque
Texas
- South Texas Veterans Healthcare System - San Antonio
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 146 participants |
| Start Date | 2024-07-09 |
| Est. Completion | 2028-06 |
| Phase | Phase 3 |
What NCT06333990 shows while recruiting
NCT06333990 is an interventional study that assigns participants to a tested intervention. The registered 146 participants enrollment target is mid-sized for trials with a published cap, below the 217-participant average among 43 other Mild Traumatic Brain Injury trials with a reported enrollment target (33% lower).
The record links to 1 condition, with Mild Traumatic Brain Injury appearing as the primary indexed condition, and to 2 interventions - of which TAU is the first listed.
NCT06333990 reports a single indexed study location in New Mexico, Texas.
Frequently Asked Questions
What is clinical trial NCT06333990 about?
NCT06333990 is a clinical study titled "Quetiapine to Reduce Post Concussive Syndrome After Mild Traumatic Brain Injury (mTBI)". A two site, 2-arm, Phase III randomized pragmatic clinical trial evaluating the effectiveness of quetiapine monotherapy in comparison to Treatment As Usual (TAU) medication management for symptoms experienced by veterans receiving rehabilitation therapy for mild traumatic brain injury (mTBI) and com...
What is the current status of trial NCT06333990?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 146 participants. The study started on 2024-07-09. Estimated completion is 2028-06.
What conditions does trial NCT06333990 study?
This clinical trial studies the following conditions: Mild Traumatic Brain Injury.
What interventions are being tested in trial NCT06333990?
The interventions under investigation include: TAU (DRUG), Quetiapine Fumarate (DRUG).
Who is sponsoring clinical trial NCT06333990?
This trial is sponsored by Foundation for Advancing Veterans' Health Research, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06333990 being conducted?
This trial has 2 study locations across New Mexico, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Mild Traumatic Brain Injury
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06333990's enrollment target sits among peer trials
146 16th of 43 higher than 28 of 43 other Mild Traumatic Brain Injury trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Mild Traumatic Brain Injury trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD)
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-
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-
Vestibular Rehabilitation App for Adults With Dizziness Related to mTBI
RECRUITING · NA
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Personalized Brain Stimulation to Treat Chronic Concussive Symptoms
RECRUITING · Phase 2
-
Risk Stratification in Children With Concussion
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-
Combined Neuromodulation and Cognitive Training for Post-mTBI Depression
RECRUITING · NA
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