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NCT06274112 · ClinicalTrials.gov registry record · NA
Using TMS to Understand Neural Processes of Social Motivation
A NA study of Major Depressive Disorder and Social Anxiety Disorder, sponsored by Auburn University.
- Recruiting
- Registry status
- NA
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT06274112: Recruiting NA study of Major Depressive Disorder and Social Anxiety Disorder, sponsored by Auburn University.
NCT06274112 is a NA study of Major Depressive Disorder and Social Anxiety Disorder that is actively recruiting participants, run by Auburn University. The registered enrollment target is 40 participants, below the 377-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (89% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06274112, a NA study of Major Depressive Disorder and Social Anxiety Disorder, is actively recruiting participants, sponsored by Auburn University.
- RECRUITING
- Registry status
- NA
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to use transcranial magnetic stimulation (TMS) to better understand the neural circuits associated with social motivation. Participant includes four study visits each that range from 1.5 - 3.0 hours in duration over approximately a one month period. The first study visit involves answering survey questions, a clinical interview, and computer tasks. The second study visit involves a magnetic resonance imaging (MRI) scan, computer tasks, and a brief TMS protocol. The second and third study visits involve a full session of TMS followed by an MRI scan and computer tasks. Adults in the Auburn/Opelika area and surrounding areas who avoid social situations, experience symptoms of depression or social anxiety, and are between 25 years old and 50 years old are eligible to participate.
Primary Outcome
Motivational responses to facial expressions as measured by the Social Approach Avoidance Paradigm (SAAP; Evans, Esterman, \& Britton, 2022). In the SAAP, participants self-report how much they would like to approach or avoid emotional facial expressions.
Conditions Studied
Interventions
- DEVICE TMS
Study Locations (1)
Alabama
- Auburn University - Auburn
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2025-09-30 |
| Est. Completion | 2029-07-31 |
| Phase | NA |
What NCT06274112 shows while recruiting
NCT06274112 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 377-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (89% lower).
The record links to 3 conditions, with Major Depressive Disorder appearing as the primary indexed condition, and to 1 intervention - of which TMS is the first listed.
NCT06274112 reports a single indexed study location in Alabama.
Frequently Asked Questions
What is clinical trial NCT06274112 about?
NCT06274112 is a clinical study titled "Using TMS to Understand Neural Processes of Social Motivation". The purpose of this study is to use transcranial magnetic stimulation (TMS) to better understand the neural circuits associated with social motivation. Participant includes four study visits each that range from 1.5 - 3.0 hours in duration over approximately a one month period. The first study visi...
What is the current status of trial NCT06274112?
This trial is currently recruiting. It is a NA study. The enrollment target is 40 participants. The study started on 2025-09-30. Estimated completion is 2029-07-31.
What conditions does trial NCT06274112 study?
This clinical trial studies the following conditions: Major Depressive Disorder, Social Anxiety Disorder, Social Avoidant Behavior.
What interventions are being tested in trial NCT06274112?
The interventions under investigation include: TMS (DEVICE).
Who is sponsoring clinical trial NCT06274112?
This trial is sponsored by Auburn University, which has 54 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06274112 being conducted?
This trial has 1 study location across Alabama. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Major Depressive Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06274112's enrollment target sits among peer trials
40 196th of 282 higher than 76 of 282 other Major Depressive Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Major Depressive Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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