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NCT06246942 · ClinicalTrials.gov registry record · NA
Physiology of Human Brain Connectivity
A NA study of Healthy, sponsored by Massachusetts General Hospital.
- Recruiting
- Registry status
- NA
- Development phase
- 80
- Enrollment target
- 1
- Study location
NCT06246942: Recruiting NA study of Healthy, sponsored by Massachusetts General Hospital.
NCT06246942 is a NA study of Healthy that is actively recruiting participants, run by Massachusetts General Hospital. The registered enrollment target is 80 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (88% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06246942, a NA study of Healthy, is actively recruiting participants, sponsored by Massachusetts General Hospital.
- RECRUITING
- Registry status
- NA
- Development phase
- 80 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to investigate the effective connectivity between different regions of the human brain in healthy participants, and the mechanisms which influence and modulate its development. Specifically, the investigators will examine the effects of cortico-cortical paired associative stimulation (ccPAS) which is induced by the application of brief (\< 1 ms) transcranial magnetic stimulation (TMS) pulses separated by a short millisecond-level time intervals ("asynchrony") to two different areas of the brain. All techniques are non-invasive and considered safe in humans: TMS, electroencephalography (EEG), and magnetic resonance imaging (MRI). Based on previous animal and human studies, it is hypothesized that ccPAS will increase or decrease effective connectivity between the stimulated areas depending on the asynchrony value. The main outcome measure is source-resolved EEG cortico-cortical evoked potentials (ccEPs) elicited by single-pulse TMS.
Primary Outcome
EEG will be recorded with a 64-channel whole-head TMS-compatible device (NeurOne 64, Bittium, Kuopio, Finland). Data will be collected before (Pre) and at 5 minutes (Post-1) and at 60 minutes (Post-2) after PAS. To record spTMS-evoked EEG responses the investigators will deliver 80 single TMS pulses to the two areas receiving PAS, one target after the other in separate runs. Effective connectivity will be measured by comparing the source-resolved EEG evoked response waveforms before (Pre) and at
Conditions Studied
Interventions
- DEVICE Single-pulse transcranial magnetic stimulation (spTMS)
- DEVICE Paired associative stimulation (PAS)
- DIAGNOSTIC_TEST Magnetic resonance imaging (MRI)
Study Locations (1)
Massachusetts
- Massachusetts General Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2024-12-13 |
| Est. Completion | 2027-04-15 |
| Phase | NA |
What NCT06246942 shows while recruiting
NCT06246942 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (88% lower).
The record links to 1 condition, with Healthy appearing as the primary indexed condition, and to 3 interventions - of which Single-pulse transcranial magnetic stimulation (spTMS) is the first listed.
NCT06246942 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT06246942 about?
NCT06246942 is a clinical study titled "Physiology of Human Brain Connectivity". The purpose of this study is to investigate the effective connectivity between different regions of the human brain in healthy participants, and the mechanisms which influence and modulate its development. Specifically, the investigators will examine the effects of cortico-cortical paired associativ...
What is the current status of trial NCT06246942?
This trial is currently recruiting. It is a NA study. The enrollment target is 80 participants. The study started on 2024-12-13. Estimated completion is 2027-04-15.
What conditions does trial NCT06246942 study?
This clinical trial studies the following conditions: Healthy.
What interventions are being tested in trial NCT06246942?
The interventions under investigation include: Single-pulse transcranial magnetic stimulation (spTMS) (DEVICE), Paired associative stimulation (PAS) (DEVICE), Magnetic resonance imaging (MRI) (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT06246942?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06246942 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06246942's enrollment target sits among peer trials
80 274th of 1090 higher than 802 of 1,090 other Healthy trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Healthy trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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