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NCT06246942 · ClinicalTrials.gov registry record · NA

Physiology of Human Brain Connectivity

A NA study of Healthy, sponsored by Massachusetts General Hospital.

Recruiting
Registry status
NA
Development phase
80
Enrollment target
1
Study location

NCT06246942: Recruiting NA study of Healthy, sponsored by Massachusetts General Hospital.

NCT06246942 is a NA study of Healthy that is actively recruiting participants, run by Massachusetts General Hospital. The registered enrollment target is 80 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (88% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT06246942, a NA study of Healthy, is actively recruiting participants, sponsored by Massachusetts General Hospital.

RECRUITING
Registry status
NA
Development phase
80 participants
Enrollment target
1
Study location

Study Summary

The purpose of this study is to investigate the effective connectivity between different regions of the human brain in healthy participants, and the mechanisms which influence and modulate its development. Specifically, the investigators will examine the effects of cortico-cortical paired associative stimulation (ccPAS) which is induced by the application of brief (\< 1 ms) transcranial magnetic stimulation (TMS) pulses separated by a short millisecond-level time intervals ("asynchrony") to two different areas of the brain. All techniques are non-invasive and considered safe in humans: TMS, electroencephalography (EEG), and magnetic resonance imaging (MRI). Based on previous animal and human studies, it is hypothesized that ccPAS will increase or decrease effective connectivity between the stimulated areas depending on the asynchrony value. The main outcome measure is source-resolved EEG cortico-cortical evoked potentials (ccEPs) elicited by single-pulse TMS.

Conditions Studied

Healthy

Interventions

  • DEVICE Single-pulse transcranial magnetic stimulation (spTMS)
  • DEVICE Paired associative stimulation (PAS)
  • DIAGNOSTIC_TEST Magnetic resonance imaging (MRI)

Study Locations (1)

Massachusetts

  • Massachusetts General Hospital - Boston

Trial Details

FieldValue
Enrollment Target 80 participants
Start Date 2024-12-13
Est. Completion 2027-04-15
Phase NA

Sponsor

Massachusetts General Hospital

2,032 total trials

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What the Registry Record Tells You About NCT06246942

The ClinicalTrials.gov registry entry for NCT06246942 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (88% lower). The listed sponsor is Massachusetts General Hospital, which has 2,032 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Healthy appearing as the primary indexed condition, and to 3 interventions - of which Single-pulse transcranial magnetic stimulation (spTMS) is the first listed.

NCT06246942 reports 1 study location spanning 1 distinct geographic area - top geographies include Massachusetts.

Frequently Asked Questions

What is clinical trial NCT06246942 about?

NCT06246942 is a clinical study titled "Physiology of Human Brain Connectivity". The purpose of this study is to investigate the effective connectivity between different regions of the human brain in healthy participants, and the mechanisms which influence and modulate its development. Specifically, the investigators will examine the effects of cortico-cortical paired associativ...

What is the current status of trial NCT06246942?

This trial is currently recruiting. It is a NA study. The enrollment target is 80 participants. The study started on 2024-12-13. Estimated completion is 2027-04-15.

What conditions does trial NCT06246942 study?

This clinical trial studies the following conditions: Healthy.

What interventions are being tested in trial NCT06246942?

The interventions under investigation include: Single-pulse transcranial magnetic stimulation (spTMS) (DEVICE), Paired associative stimulation (PAS) (DEVICE), Magnetic resonance imaging (MRI) (DIAGNOSTIC_TEST).

Who is sponsoring clinical trial NCT06246942?

This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06246942 being conducted?

This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.