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NCT06180967 · ClinicalTrials.gov registry record · Phase 1

A Drug Drug Interaction (DDI) Study of Pirtobrutinib (LOXO-305) and Different Formulations of Midazolam in Healthy Participants

A Phase 1 study of Healthy, sponsored by Eli Lilly and Company.

Completed
Registry status
Phase 1
Development phase
15
Enrollment target
1
Study location

NCT06180967 is a Phase 1 study of Healthy that has completed, run by Eli Lilly and Company. The registered enrollment target is 15 participants, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT06180967, a Phase 1 study of Healthy, has completed, sponsored by Eli Lilly and Company.

COMPLETED
Registry status
Phase 1
Development phase
15 participants
Enrollment target
1
Study location

Study Summary

The main purpose of this study is to assess the effect of Pirtobrutinib (LOXO-305) on how fast different formulations of midazolam gets into the blood stream and how long it takes the body to remove it when administered in healthy participants. The study will also access how much endogenous coproporphyrins I and III as biomarkers of OATP1B1 and OATP1B3 is in the bloodstream and how the body handles and eliminates them following single and multiple oral doses of Pirtobrutinib. Safety and tolerability of Pirtobrutinib will also be evaluated. For each participant, the total duration of the study will be 59 days, including screening.

Conditions Studied

Healthy

Interventions

  • DRUG Pirtobrutinib
  • DRUG Midazolam Syrup
  • DRUG Midazolam Solution

Study Locations (1)

Florida

  • Covance Clinical Research Unit - Daytona Beach

Trial Details

FieldValue
Enrollment Target 15 participants
Start Date 2020-09-03
Est. Completion 2020-10-20
Phase Phase 1

Sponsor

Eli Lilly and Company

1,341 total trials

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What the Registry Record Tells You About NCT06180967

The ClinicalTrials.gov registry entry for NCT06180967 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 15 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 647-participant average among 1,090 other Healthy trials with a reported enrollment target (98% lower). The listed sponsor is Eli Lilly and Company, which has 1,341 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Healthy appearing as the primary indexed condition, and to 3 interventions - of which Pirtobrutinib is the first listed.

NCT06180967 reports 1 study location spanning 1 distinct geographic area - top geographies include Florida.

Frequently Asked Questions

What is clinical trial NCT06180967 about?

NCT06180967 is a clinical study titled "A Drug Drug Interaction (DDI) Study of Pirtobrutinib (LOXO-305) and Different Formulations of Midazolam in Healthy Participants". The main purpose of this study is to assess the effect of Pirtobrutinib (LOXO-305) on how fast different formulations of midazolam gets into the blood stream and how long it takes the body to remove it when administered in healthy participants. The study will also access how much endogenous copropor...

What is the current status of trial NCT06180967?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 15 participants. The study started on 2020-09-03. Estimated completion is 2020-10-20.

What conditions does trial NCT06180967 study?

This clinical trial studies the following conditions: Healthy.

What interventions are being tested in trial NCT06180967?

The interventions under investigation include: Pirtobrutinib (DRUG), Midazolam Syrup (DRUG), Midazolam Solution (DRUG).

Who is sponsoring clinical trial NCT06180967?

This trial is sponsored by Eli Lilly and Company, which has 1,341 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT06180967 being conducted?

This trial has 1 study location across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.