Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT06127147 · ClinicalTrials.gov registry record · NA
High-intensity Inspiratory Muscle Training as a Pre-cardiac Rehabilitation in Heart Disease
A NA study of Coronary Artery Bypass Graft and CABG, sponsored by University of Illinois at Chicago.
- Completed
- Registry status
- NA
- Development phase
- 11
- Enrollment target
- 2
- Study locations
NCT06127147: Completed NA study of Coronary Artery Bypass Graft and CABG, sponsored by University of Illinois at Chicago.
NCT06127147 is a NA study of Coronary Artery Bypass Graft and CABG that has completed, run by University of Illinois at Chicago. The registered enrollment target is 11 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06127147, a NA study of Coronary Artery Bypass Graft and CABG, has completed, sponsored by University of Illinois at Chicago.
- COMPLETED
- Registry status
- NA
- Development phase
- 11 participants
- Enrollment target
- 2
- Study locations
Study Summary
Background/aim: Endothelial function is closely associated with coronary artery health among individuals being treated for heart disease. An impairment in endothelial function promotes arterial stiffening that directly contributes to elevated systolic blood pressure as a result of increased vascular resistance. Inspiratory muscle training is simply a form of training consisting of repeated inspirations against resistance. Inspiratory muscle training has also been applied to patients with chronic disease or as an additional therapy for cardiac rehabilitation and it has proven to be safe in these groups. Few studies in the literature examined the effects of high-intensity inspiratory muscle training in this population, however, these studies did not examine the direct effects of inspiratory muscle training on vascular function. To the best of our knowledge, the effects of inspiratory muscle training in patients with heart disease on endothelial function and arterial stiffness prior to starting cardiac rehabilitation have not been investigated. This study aims to investigate and interpret whether high-intensity inspiratory muscle training, beyond the usual care of heart disease, improves endothelial function and arterial stiffness. Methods: The study was designed as a randomized controlled trial. Patients will be allocated for inspiratory muscle training (IMT) with 60% of maximum inspiratory pressure (MIP) or sham inspiratory muscle training (Sham-control), for 4 weeks. In both groups, before and after 4-week training, cardiovascular functions will be measured and compared.
Primary Outcome
maximal inspiratory pressure (MIP) is the highest pressure measured during inspiration will be used.
Conditions Studied
Interventions
- DEVICE IMT
- DEVICE Sham-IMT
Study Locations (2)
Illinois
- University of Illinois at Chicago - Chicago
- University of Illinois Chicago - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 11 participants |
| Start Date | 2023-12-20 |
| Est. Completion | 2024-06-15 |
| Phase | NA |
What the finished NCT06127147 record still lists
NCT06127147 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 11 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 2 conditions, with Coronary Artery Bypass Graft appearing as the primary indexed condition, and to 2 interventions - of which IMT is the first listed.
NCT06127147 reports a single indexed study location in Illinois.
Frequently Asked Questions
What is clinical trial NCT06127147 about?
NCT06127147 is a clinical study titled "High-intensity Inspiratory Muscle Training as a Pre-cardiac Rehabilitation in Heart Disease". Background/aim: Endothelial function is closely associated with coronary artery health among individuals being treated for heart disease. An impairment in endothelial function promotes arterial stiffening that directly contributes to elevated systolic blood pressure as a result of increased vascular...
What is the current status of trial NCT06127147?
This trial is currently completed. It is a NA study. The enrollment target is 11 participants. The study started on 2023-12-20. Estimated completion is 2024-06-15.
What conditions does trial NCT06127147 study?
This clinical trial studies the following conditions: Coronary Artery Bypass Graft, CABG.
What interventions are being tested in trial NCT06127147?
The interventions under investigation include: IMT (DEVICE), Sham-IMT (DEVICE).
Who is sponsoring clinical trial NCT06127147?
This trial is sponsored by University of Illinois at Chicago, which has 430 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06127147 being conducted?
This trial has 2 study locations across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Coronary Artery Bypass Graft
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06127147's enrollment target sits among peer trials
11 1927th of 2000 higher than 74 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT03114462 · 11 participants · Phase 1
Trial of Stereotactic HYpofractionateD RadioAblative (HYDRA) Treatment of Laryngeal Cancer
- NCT06039709 · 11 participants · Phase 1
Sonodynamic Therapy in Patients With Recurrent GBM
- NCT06425380 · 11 participants · NA
Pilot Open-Label Trial of Resistant Potato Starch in Patients With Cirrhosis and Overt Hepatic Encephalopathy
- NCT06472661 · 11 participants · Early Phase 1
FUSA With Intratumoral PolyICLC in Regionally Advanced Resectable Melanoma
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI