Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

ACTIVE NOT RECRUITING Phase 3

Study of Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Obinutuzumab in Participants With Chronic Lymphocytic Leukemia (CLL)

NCT06073821 · View on ClinicalTrials.gov ↗

Study Summary

The main objective of this study is to compare the efficacy of sonrotoclax plus zanubrutinib versus venetoclax plus obinutuzumab in participants with chronic lymphocytic leukemia (CLL)

Conditions Studied

Interventions

  • DRUG Zanubrutinib
  • DRUG Obinutuzumab
  • DRUG Venetoclax
  • DRUG Sonrotoclax

Study Locations (20)

California

  • City of Hope National Medical Center — Duarte
  • University of California San Diego (Ucsd) Moores Cancer Center — La Jolla
  • Valkyrie Clinical Trials — Los Angeles
  • UCLA Department of Medicine Hematologyoncology — Los Angeles
  • Chao Family Comprehensive Cancer Center — Orange
  • Stanford Medicine — Palo Alto

Florida

  • Mount Sinai Comprehensive Cancer Center — Miami Beach
  • Moffitt Cancer Center — Tampa

Illinois

  • Northwestern University — Chicago
  • Illinois Cancercare, Pc — Peoria

Iowa

  • University of Iowa Hospitals and Clinics — Iowa City
  • Mission Cancer and Blood — Waukee

Alaska

  • Alaska Oncology and Hematology, Llc — Anchorage

Colorado

  • University of Colorado Cancer Center — Aurora

District of Columbia

  • Medstar Georgetown University Hospital — Washington D.C.

Georgia

  • Southeastern Regional Medical Center — Newnan

Trial Details

FieldValue
Enrollment Target 652 participants
Start Date 2023-11-11
Est. Completion 2032-12
Phase Phase 3

Sponsor

BeOne Medicines

138 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06073821

The ClinicalTrials.gov registry entry for NCT06073821 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 652 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is BeOne Medicines, which has 138 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with CLL appearing as the primary indexed condition, and to 4 interventions — of which Zanubrutinib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06073821 reports 20 study locations spanning 12 distinct geographic areas — top geographies include California, Florida, Illinois. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06073821 about?

NCT06073821 is a clinical study titled "Study of Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Obinutuzumab in Participants With Chronic Lymphocytic Leukemia (CLL)". The main objective of this study is to compare the efficacy of sonrotoclax plus zanubrutinib versus venetoclax plus obinutuzumab in participants with chronic lymphocytic leukemia (CLL)

What is the current status of trial NCT06073821?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 652 participants. The study started on 2023-11-11. Estimated completion is 2032-12.

What conditions does trial NCT06073821 study?

This clinical trial studies the following conditions: CLL. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06073821?

The interventions under investigation include: Zanubrutinib (DRUG), Obinutuzumab (DRUG), Venetoclax (DRUG), Sonrotoclax (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06073821?

This trial is sponsored by BeOne Medicines, which has 138 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06073821 being conducted?

This trial has 20 study locations across Alaska, California, Colorado, District of Columbia, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial