Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05586776 · ClinicalTrials.gov registry record · Phase 4
Decolonization to Reduce After-Surgery Events of Surgical Site Infection
A Phase 4 study of Surgical Site Infection, sponsored by University of California, Irvine.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 2,700
- Enrollment target
- 4
- Study locations
NCT05586776: Recruiting Phase 4 study of Surgical Site Infection, sponsored by University of California, Irvine.
NCT05586776 is a Phase 4 study of Surgical Site Infection that is actively recruiting participants, run by University of California, Irvine. The registered enrollment target is 2,700 participants, above the 460-participant average among 25 other Surgical Site Infection trials with a reported enrollment target (487% higher). The trial reports 4 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05586776, a Phase 4 study of Surgical Site Infection, is actively recruiting participants, sponsored by University of California, Irvine.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 2,700 participants
- Enrollment target
- 4
- Study locations
Study Summary
The DECREASE SSI Trial (Decolonization to Reduce After-Surgery Events of Surgical Site Infection) is a two-arm multi-center individual placebo-controlled randomized (2,700 participants randomized 1:1) clinical trial to reduce post-discharge surgical site infection following open colon or small bowel surgery by comparing chlorhexidine bathing plus nasal mupirocin in the 30 days following discharge to soap without antiseptic properties (placebo) and placebo nasal ointment. This trial seeks to enhance the care of the 675,000 patients annually who undergo colon and small bowel surgery by finding simple and efficacious interventions to reduce SSI.
Conditions Studied
Interventions
- DRUG 4% Chlorhexidine Gluconate
- DRUG 2% Mupirocin
- DRUG Soap Without Antiseptic Properties (Placebo)
- DRUG Placebo Nasal Ointment
Study Locations (4)
California
- Hoag Memorial Hospital Presbyterian - Newport Beach
- University of California, Irvine Medical Center - Orange
- University of California, Davis Medical Center - Sacramento
- University of California, San Francisco Medical Center - San Francisco
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2,700 participants |
| Start Date | 2023-01-17 |
| Est. Completion | 2028-12 |
| Phase | Phase 4 |
What NCT05586776 shows while recruiting
NCT05586776 is an interventional study that assigns participants to a tested intervention. Its 2,700 participants enrollment target places it among the larger protocols in the corpus, above the 460-participant average among 25 other Surgical Site Infection trials with a reported enrollment target (487% higher).
The record links to 1 condition, with Surgical Site Infection appearing as the primary indexed condition, and to 4 interventions - of which 4% Chlorhexidine Gluconate is the first listed.
NCT05586776 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT05586776 about?
NCT05586776 is a clinical study titled "Decolonization to Reduce After-Surgery Events of Surgical Site Infection". The DECREASE SSI Trial (Decolonization to Reduce After-Surgery Events of Surgical Site Infection) is a two-arm multi-center individual placebo-controlled randomized (2,700 participants randomized 1:1) clinical trial to reduce post-discharge surgical site infection following open colon or small bowel...
What is the current status of trial NCT05586776?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 2,700 participants. The study started on 2023-01-17. Estimated completion is 2028-12.
What conditions does trial NCT05586776 study?
This clinical trial studies the following conditions: Surgical Site Infection.
What interventions are being tested in trial NCT05586776?
The interventions under investigation include: 4% Chlorhexidine Gluconate (DRUG), 2% Mupirocin (DRUG), Soap Without Antiseptic Properties (Placebo) (DRUG), Placebo Nasal Ointment (DRUG).
Who is sponsoring clinical trial NCT05586776?
This trial is sponsored by University of California, Irvine, which has 368 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05586776 being conducted?
This trial has 4 study locations across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Surgical Site Infection
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05586776's enrollment target sits among peer trials
2,700 1st of 25 higher than 25 of 25 other Surgical Site Infection trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Surgical Site Infection trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Ostomy Primary Closure With 0.1% Betaine/Polyhexanide Wound Irrigation Compared to Pursestring Closure
RECRUITING · Phase 4
-
Utility of Single-dose Oral Antibiotic Prophylaxis in Prevention of Surgical Site Infection in Dermatologic Surgery
RECRUITING · Phase 4
-
PVI to Prevent S. Aureus SSI After Fixation of HELEF (POTENT Study)
ACTIVE NOT RECRUITING · Phase 4
-
Pre-operative Aqueous Antiseptic Skin Solutions in Open Fractures
COMPLETED · Phase 4
-
Topical Antibiotic Prophylaxis for Eyelids
COMPLETED · Phase 4
-
Multicenter Infection Surveillance Study Following Open Heart Surgery
COMPLETED · Phase 4
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT04073420 · 2,700 participants
Medtronic Cardiac Surgery PMCF Registry
- NCT05125939 · 2,700 participants
Can Overall Adenoma Detection Rate Replace Screening Adenoma Detection Rate ? Multicenter Study
- NCT06052267 · 2,700 participants · Phase 3
A Study to Test if a Fixed-Dose Combination of Fluticasone Propionate/Albuterol Sulfate is Effective in Preventing Asthma Exacerbations
- NCT07029490 · 2,700 participants · NA
Enhancing Mammography Programs for Outreach, Wellness, Education, and Resources (EMPOWER) in Underserved Populations Study
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI