Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer
NCT05999994 · View on ClinicalTrials.gov ↗
Study Summary
The main purpose of the master is to help the research sites and sponsor carry out several clinical trials more efficiently by providing a common research protocol. Individual clinical trials under this master protocol define drug/disease-specific research goals and activities to test them. New studies will be added as new drugs emerge against different cancers. Participation in the trial will depend on how long the benefit lasts.
Conditions Studied
Interventions
- DRUG Cyclophosphamide
- DRUG Docetaxel
- DRUG Gemcitabine
- DRUG Ramucirumab
- DRUG Vinorelbine
Study Locations (20)
California
- Childrens Hospital of Los Angeles — Los Angeles
- UCLA Medical Center — Los Angeles
- Children's Hospital of Orange County — Orange
Arizona
- Phoenix Children's Hospital — Phoenix
- Phoenix Children's Hospital — Phoenix
Florida
- Golisano Children's Hospital of Southwest Florida — Fort Myers
- Mayo Clinic in Florida — Jacksonville
Missouri
- Children's Mercy Hospital — Kansas City
- Washington University Medical School — St Louis
Alabama
- Childrens Hospital of Alabama — Birmingham
Colorado
- Children's Hospital of Colorado — Denver
District of Columbia
- Children's National Medical Center — Washington D.C.
Georgia
- Children's Healthcare of Atlanta, Inc. at Egleston — Atlanta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 105 participants |
| Start Date | 2020-01-22 |
| Est. Completion | 2027-05 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05999994
The ClinicalTrials.gov registry entry for NCT05999994 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 105 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 3 conditions, with Neoplasms appearing as the primary indexed condition, and to 5 interventions — of which Cyclophosphamide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05999994 reports 20 study locations spanning 15 distinct geographic areas — top geographies include California, Arizona, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05999994 about?
NCT05999994 is a clinical study titled "A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer". The main purpose of the master is to help the research sites and sponsor carry out several clinical trials more efficiently by providing a common research protocol. Individual clinical trials under this master protocol define drug/disease-specific research goals and activities to test them. New stud...
What is the current status of trial NCT05999994?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 105 participants. The study started on 2020-01-22. Estimated completion is 2027-05.
What conditions does trial NCT05999994 study?
This clinical trial studies the following conditions: Neoplasms, Adolescent, Child. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT05999994?
The interventions under investigation include: Cyclophosphamide (DRUG), Docetaxel (DRUG), Gemcitabine (DRUG), Ramucirumab (DRUG), Vinorelbine (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT05999994?
This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05999994 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Colorado, District of Columbia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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