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NCT05993299 · ClinicalTrials.gov registry record · Phase 2
Study to Evaluate Safety and Antitumor Activity of Lete-Cel (GSK3377794) in HLA-A2+ Participants With NY-ESO-1 Positive Previously Untreated Advanced (Metastatic or Unresectable) Synovial Sarcoma and Myxoid/Round Cell Liposarcoma
A Phase 2 study of Neoplasms, sponsored by USWM, LLC (dba US WorldMeds).
- Active
- Registry status
- Phase 2
- Development phase
- 7
- Enrollment target
- 20
- Study locations
NCT05993299 is a Phase 2 study of Neoplasms that is active but no longer recruiting, run by USWM, LLC (dba US WorldMeds). The registered enrollment target is 7 participants, below the 1,621-participant average among 158 other Neoplasms trials with a reported enrollment target (100% lower). The trial reports 20 study locations across 16 states.
The verdict
NCT05993299, a Phase 2 study of Neoplasms, is active but no longer recruiting, sponsored by USWM, LLC (dba US WorldMeds).
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 7 participants
- Enrollment target
- 20
- Study locations
Study Summary
This trial will evaluate safety and efficacy of human engineered T-cell therapies, in participants with advanced tumors. This trial is a sub study of the Master study NCT03967223.
Conditions Studied
Interventions
- DRUG Cyclophosphamide
- DRUG Fludarabine
- DRUG Letetresgene autoleucel
Study Locations (20)
California
- City of Hope National Medical Center - Duarte
- Stanford Hospital and Clinics - Stanford
Massachusetts
- Dana Farber Cancer Institute - Boston
- Massachusetts General Hospital - Boston
Minnesota
- Minnesota Oncology Hematology - Minneapolis
- Mayo Clinic Rochester - Rochester
Texas
- University Of Texas Southwestern Medical Center - Dallas
- University of Texas Southwestern Medical Center - Dallas
Colorado
- Sarah Cannon Research Institute - Denver
Florida
- Mayo Clinic Jacksonville - Jacksonville
Illinois
- University of Chicago - Chicago
Iowa
- University of Iowa College of Medicine - Iowa City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 7 participants |
| Start Date | 2019-12-31 |
| Est. Completion | 2026-07-01 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05993299
The ClinicalTrials.gov registry entry for NCT05993299 describes a study currently listed as active not recruiting, categorized as Phase 2. The registered enrollment target is 7 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,621-participant average among 158 other Neoplasms trials with a reported enrollment target (100% lower). The listed sponsor is USWM, LLC (dba US WorldMeds), which has 16 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Neoplasms appearing as the primary indexed condition, and to 3 interventions - of which Cyclophosphamide is the first listed.
NCT05993299 reports 20 study locations spanning 16 distinct geographic areas - top geographies include California, Massachusetts, Minnesota.
Frequently Asked Questions
What is clinical trial NCT05993299 about?
NCT05993299 is a clinical study titled "Study to Evaluate Safety and Antitumor Activity of Lete-Cel (GSK3377794) in HLA-A2+ Participants With NY-ESO-1 Positive Previously Untreated Advanced (Metastatic or Unresectable) Synovial Sarcoma and Myxoid/Round Cell Liposarcoma". This trial will evaluate safety and efficacy of human engineered T-cell therapies, in participants with advanced tumors. This trial is a sub study of the Master study NCT03967223.
What is the current status of trial NCT05993299?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 7 participants. The study started on 2019-12-31. Estimated completion is 2026-07-01.
What conditions does trial NCT05993299 study?
This clinical trial studies the following conditions: Neoplasms.
What interventions are being tested in trial NCT05993299?
The interventions under investigation include: Cyclophosphamide (DRUG), Fludarabine (DRUG), Letetresgene autoleucel (DRUG).
Who is sponsoring clinical trial NCT05993299?
This trial is sponsored by USWM, LLC (dba US WorldMeds), which has 16 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05993299 being conducted?
This trial has 20 study locations across California, Colorado, Florida, Illinois, Iowa. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.