Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05999968 · ClinicalTrials.gov registry record · Phase 1
Abemaciclib Plus Darolutamide in Prostate Cancer That Has Spread After Initial Treatment
A Phase 1 study of Prostatic Neoplasms, sponsored by Eli Lilly and Company.
- Completed
- Registry status
- Phase 1
- Development phase
- 10
- Enrollment target
- 13
- Study locations
NCT05999968 is a Phase 1 study of Prostatic Neoplasms that has completed, run by Eli Lilly and Company. The registered enrollment target is 10 participants, below the 514-participant average among 65 other Prostatic Neoplasms trials with a reported enrollment target (98% lower). The trial reports 13 study locations across 8 states.
The verdict
NCT05999968, a Phase 1 study of Prostatic Neoplasms, has completed, sponsored by Eli Lilly and Company.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 10 participants
- Enrollment target
- 13
- Study locations
Study Summary
The main purpose of this study is to learn more about the safety and tolerability of abemaciclib when given in combination with darolutamide to participants with prostate cancer that has spread after initial treatment. Participation may last up to 32 months.
Conditions Studied
Interventions
- DRUG Darolutamide
- DRUG Abemaciclib
- DRUG LHRH agonist/antagonist
Study Locations (13)
Other
- Universitaetsklinikum Hamburg-Eppendorf - Hamburg
- Hospital Infanta Cristina - Badajoz
- Hospital Universitario Virgen Del Rocio - Seville
Madrid, Comunidad de
- Hospital General Universitario Gregorio Marañon - Madrid
- Hospital Universitario Ramón y Cajal - Madrid
- Hospital Universitario 12 de Octubre - Madrid
New York
- Perlmutter Cancer Center at NYU Langone Hospital - Long Island - Mineola
- Laura and Isaac Perlmutter Cancer Center - New York
Arkansas
- Highlands Oncology Group - Springdale
Baden-Wurttemberg
- Studienpraxis Urologie - Nürtingen
Bavaria
- Klinikum Rechts Der Isar Der Technischen Universität München - Munich
Schleswig-Holstein
- Universitätsklinikum Schleswig-Holstein - Lübeck
Catalunya [Cataluña]
- Instituto Catalan de Oncologia - Hospital Duran i Reynals - L'Hospitalet de Llobregat
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2024-01-12 |
| Est. Completion | 2026-01-21 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05999968
The ClinicalTrials.gov registry entry for NCT05999968 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 10 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 514-participant average among 65 other Prostatic Neoplasms trials with a reported enrollment target (98% lower). The listed sponsor is Eli Lilly and Company, which has 1,341 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Prostatic Neoplasms appearing as the primary indexed condition, and to 3 interventions - of which Darolutamide is the first listed.
NCT05999968 reports 13 study locations spanning 8 distinct geographic areas - top geographies include Other, Madrid, Comunidad de, New York.
Frequently Asked Questions
What is clinical trial NCT05999968 about?
NCT05999968 is a clinical study titled "Abemaciclib Plus Darolutamide in Prostate Cancer That Has Spread After Initial Treatment". The main purpose of this study is to learn more about the safety and tolerability of abemaciclib when given in combination with darolutamide to participants with prostate cancer that has spread after initial treatment. Participation may last up to 32 months.
What is the current status of trial NCT05999968?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 10 participants. The study started on 2024-01-12. Estimated completion is 2026-01-21.
What conditions does trial NCT05999968 study?
This clinical trial studies the following conditions: Prostatic Neoplasms.
What interventions are being tested in trial NCT05999968?
The interventions under investigation include: Darolutamide (DRUG), Abemaciclib (DRUG), LHRH agonist/antagonist (DRUG).
Who is sponsoring clinical trial NCT05999968?
This trial is sponsored by Eli Lilly and Company, which has 1,341 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05999968 being conducted?
This trial has 13 study locations across Arkansas, New York, Baden-Wurttemberg, Bavaria, Schleswig-Holstein. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Prostatic Neoplasms
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
Open-Label Study of Pocenbrodib Alone and in Combination With Abiraterone Acetate, Olaparib, or 177Lu-PSMA-617
RECRUITING · Phase 1
-
A Study of JNJ-78278343 in Combination With JNJ-95298177 for Treatment of Prostate Cancer
RECRUITING · Phase 1
-
A Study of Pasritamig (JNJ-78278343) in Combination With JNJ-86974680 for Treatment of Prostate Cancer
RECRUITING · Phase 1
-
Anti-tumour Activity of (177Lu) rhPSMA-10.1 Injection
RECRUITING · Phase 1
-
HSV-tk + Valacyclovir Therapy in Combination With Brachytherapy for Recurrent Prostate Cancer
RECRUITING · Phase 1
-
A Study of DM002 in Patients With Advanced Solid Tumors
RECRUITING · Phase 1
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.