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NCT05992311 · ClinicalTrials.gov registry record · Phase 1

Clinical Evaluation of Montelukast in Veterans With Gulf War Illness

A Phase 1 study of Gulf War Syndrome, sponsored by Baylor College of Medicine.

Recruiting
Registry status
Phase 1
Development phase
80
Enrollment target
1
Study location

NCT05992311 is a Phase 1 study of Gulf War Syndrome that is actively recruiting participants, run by Baylor College of Medicine. The registered enrollment target is 80 participants, below the 125-participant average among 8 other Gulf War Syndrome trials with a reported enrollment target (36% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT05992311, a Phase 1 study of Gulf War Syndrome, is actively recruiting participants, sponsored by Baylor College of Medicine.

RECRUITING
Registry status
Phase 1
Development phase
80 participants
Enrollment target
1
Study location

Study Summary

The study addresses the pre-clinical promise of Montelukast (MLK) for improving brain function in veterans with Gulf War Illness (GWI). MLK, a US Food and Drug administration (FDA)-approved drug for asthma, has shown efficacy in an animal model of GWI to improve cognitive and mood function through modulation of leukotriene signaling and suppression of neuroinflammation.

Conditions Studied

Gulf War Syndrome

Interventions

  • OTHER Placebo
  • DRUG Montelukast

Study Locations (1)

Texas

  • Michael E. DeBakey VA Medical Center - Houston

Trial Details

FieldValue
Enrollment Target 80 participants
Start Date 2025-08-15
Est. Completion 2028-08
Phase Phase 1

Sponsor

Baylor College of Medicine

616 total trials

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What the Registry Record Tells You About NCT05992311

The ClinicalTrials.gov registry entry for NCT05992311 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 80 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 125-participant average among 8 other Gulf War Syndrome trials with a reported enrollment target (36% lower). The listed sponsor is Baylor College of Medicine, which has 616 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Gulf War Syndrome appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.

NCT05992311 reports 1 study location spanning 1 distinct geographic area - top geographies include Texas.

Frequently Asked Questions

What is clinical trial NCT05992311 about?

NCT05992311 is a clinical study titled "Clinical Evaluation of Montelukast in Veterans With Gulf War Illness". The study addresses the pre-clinical promise of Montelukast (MLK) for improving brain function in veterans with Gulf War Illness (GWI). MLK, a US Food and Drug administration (FDA)-approved drug for asthma, has shown efficacy in an animal model of GWI to improve cognitive and mood function through m...

What is the current status of trial NCT05992311?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 80 participants. The study started on 2025-08-15. Estimated completion is 2028-08.

What conditions does trial NCT05992311 study?

This clinical trial studies the following conditions: Gulf War Syndrome.

What interventions are being tested in trial NCT05992311?

The interventions under investigation include: Placebo (OTHER), Montelukast (DRUG).

Who is sponsoring clinical trial NCT05992311?

This trial is sponsored by Baylor College of Medicine, which has 616 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05992311 being conducted?

This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.