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GWICTIC: NAC Mechanistic Study in Gulf War Veterans
NCT04987775 · View on ClinicalTrials.gov ↗
Study Summary
This mechanistic study will test if NAC affects chronic oxidative stress and depletion of antioxidants in GWI participants. Blood specimen collection and neuroimaging will be used to determine whether NAC affects serum glutathione (GSH) concentration and oxidative stress in the CNS when compared to placebo.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG N-Acetyl Cysteine
Study Locations (7)
California
- VA Palo Alto Health Care System War Related Illness and Injury Study Center — Palo Alto
Florida
- Nova Southeastern University — Fort Lauderdale
Massachusetts
- Boston University Medical School — Boston
New Jersey
- VA New Jersey Health Care System War Related Illness and Injury Study Center — East Orange
New York
- Weill Cornell Medical College — New York
North Carolina
- RTI International — Durham
Texas
- Michael E. DeBakey VA Medical Center — Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 170 participants |
| Start Date | 2023-11-30 |
| Est. Completion | 2026-04 |
| Phase | Early Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04987775
The ClinicalTrials.gov registry entry for NCT04987775 describes a study currently listed as recruiting. It is categorized as Early Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 170 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Nova Southeastern University, which has 82 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Gulf War Syndrome appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04987775 reports 7 study locations spanning 7 distinct geographic areas — top geographies include California, Florida, Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04987775 about?
NCT04987775 is a clinical study titled "GWICTIC: NAC Mechanistic Study in Gulf War Veterans". This mechanistic study will test if NAC affects chronic oxidative stress and depletion of antioxidants in GWI participants. Blood specimen collection and neuroimaging will be used to determine whether NAC affects serum glutathione (GSH) concentration and oxidative stress in the CNS when compared to ...
What is the current status of trial NCT04987775?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 170 participants. The study started on 2023-11-30. Estimated completion is 2026-04.
What conditions does trial NCT04987775 study?
This clinical trial studies the following conditions: Gulf War Syndrome. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04987775?
The interventions under investigation include: Placebo (DRUG), N-Acetyl Cysteine (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04987775?
This trial is sponsored by Nova Southeastern University, which has 82 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04987775 being conducted?
This trial has 7 study locations across California, Florida, Massachusetts, New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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