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NCT04987775 · ClinicalTrials.gov registry record · Early Phase 1
GWICTIC: NAC Mechanistic Study in Gulf War Veterans
A Early Phase 1 study of Gulf War Syndrome, sponsored by Nova Southeastern University.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 170
- Enrollment target
- 7
- Study locations
NCT04987775: Recruiting Early Phase 1 study of Gulf War Syndrome, sponsored by Nova Southeastern University.
NCT04987775 is a Early Phase 1 study of Gulf War Syndrome that is actively recruiting participants, run by Nova Southeastern University. The registered enrollment target is 170 participants, above the 114-participant average among 8 other Gulf War Syndrome trials with a reported enrollment target (49% higher). The trial reports 7 study locations across 7 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04987775, a Early Phase 1 study of Gulf War Syndrome, is actively recruiting participants, sponsored by Nova Southeastern University.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 170 participants
- Enrollment target
- 7
- Study locations
Study Summary
This mechanistic study will test if NAC affects chronic oxidative stress and depletion of antioxidants in GWI participants. Blood specimen collection and neuroimaging will be used to determine whether NAC affects serum glutathione (GSH) concentration and oxidative stress in the CNS when compared to placebo.
Primary Outcome
Change in glutathione levels after NAC supplementation compared to placebo in participants with gulf war illness (GWI)
Conditions Studied
Interventions
- DRUG Placebo
- DRUG N-Acetyl Cysteine
Study Locations (7)
California
- VA Palo Alto Health Care System War Related Illness and Injury Study Center - Palo Alto
Florida
- Nova Southeastern University - Fort Lauderdale
Massachusetts
- Boston University Medical School - Boston
New Jersey
- VA New Jersey Health Care System War Related Illness and Injury Study Center - East Orange
New York
- Weill Cornell Medical College - New York
North Carolina
- RTI International - Durham
Texas
- Michael E. DeBakey VA Medical Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 170 participants |
| Start Date | 2023-11-30 |
| Est. Completion | 2026-04 |
| Phase | Early Phase 1 |
What NCT04987775 shows while recruiting
NCT04987775 is an interventional study that assigns participants to a tested intervention. The registered 170 participants enrollment target is mid-sized for trials with a published cap, above the 114-participant average among 8 other Gulf War Syndrome trials with a reported enrollment target (49% higher).
The record links to 1 condition, with Gulf War Syndrome appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT04987775 lists 7 locations in 7 states (California, Florida, Massachusetts).
Frequently Asked Questions
What is clinical trial NCT04987775 about?
NCT04987775 is a clinical study titled "GWICTIC: NAC Mechanistic Study in Gulf War Veterans". This mechanistic study will test if NAC affects chronic oxidative stress and depletion of antioxidants in GWI participants. Blood specimen collection and neuroimaging will be used to determine whether NAC affects serum glutathione (GSH) concentration and oxidative stress in the CNS when compared to ...
What is the current status of trial NCT04987775?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 170 participants. The study started on 2023-11-30. Estimated completion is 2026-04.
What conditions does trial NCT04987775 study?
This clinical trial studies the following conditions: Gulf War Syndrome.
What interventions are being tested in trial NCT04987775?
The interventions under investigation include: Placebo (DRUG), N-Acetyl Cysteine (DRUG).
Who is sponsoring clinical trial NCT04987775?
This trial is sponsored by Nova Southeastern University, which has 71 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04987775 being conducted?
This trial has 7 study locations across California, Florida, Massachusetts, New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Gulf War Syndrome
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04987775's enrollment target sits among peer trials
170 3rd of 8 higher than 6 of 8 other Gulf War Syndrome trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Gulf War Syndrome trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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