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NCT05978804 · ClinicalTrials.gov registry record · NA
Home-based tDCS in Frontotemporal Dementia or Alzheimer's Disease
A NA study, sponsored by Johns Hopkins University.
- Terminated
- Registry status
- NA
- Development phase
- 36
- Enrollment target
NCT05978804: Clinical Trial NA study, sponsored by Johns Hopkins University.
NCT05978804 is a NA study that was terminated before completion, run by Johns Hopkins University. The registered enrollment target is 36 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05978804, a NA study, was terminated before completion, sponsored by Johns Hopkins University.
- TERMINATED
- Registry status
- NA
- Development phase
- 36 participants
- Enrollment target
Study Summary
The primary objective of this research is to evaluate the effects of non-invasive brain stimulation and computerized cognitive training on executive functioning in individuals with Primary Progressive Aphasia (PPA), mild cognitive impairment (MCI), or dementia. In this study, investigators will use transcranial direct current stimulation (tDCS) to stimulate the left dorsolateral prefrontal cortex (DLPFC). Previous studies have demonstrated that tDCS over the DLPFC led to improvements in attention deficit caused by stroke, Parkinson's Disease, and major depression as well as language deficits caused by neurodegenerative conditions such as primary progressive aphasia or mild cognitive impairment. The investigators seek to expand on this literature by investigating how anodal tDCS paired with and without cognitive training will impact executive functioning in PPA with Frontotemporal Dementia or Alzheimer's Disease pathology and Mild Cognitive Impairment/Alzheimer's Disease (e.g. shifting, updating, monitoring, and manipulation).
Primary Outcome
A single language composite outcome will be generated by computing the mean of the z-scores the following oral and written naming, spelling, and sentence comprehension and repetition tasks: Philadelphia Naming Test (Short Form), Boston Naming Test, Hopkins Action Naming Assessment, Hopkins Dysgraphia Battery, National Alzheimer's Coordinating Center Sentence Repetition. The investigators will take the z-score for each task and aggregate them in order to get a composite z-score.
Interventions
- OTHER Computerized Cognitive Training
- DEVICE Active tDCS (tDCS) on DLPFC
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 36 participants |
| Start Date | 2023-08-10 |
| Est. Completion | 2025-09-10 |
| Phase | NA |
Why NCT05978804 stopped before completion
NCT05978804 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 36 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 2 interventions - of which Computerized Cognitive Training is the first listed.
NCT05978804 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05978804 about?
NCT05978804 is a clinical study titled "Home-based tDCS in Frontotemporal Dementia or Alzheimer's Disease". The primary objective of this research is to evaluate the effects of non-invasive brain stimulation and computerized cognitive training on executive functioning in individuals with Primary Progressive Aphasia (PPA), mild cognitive impairment (MCI), or dementia. In this study, investigators will use ...
What is the current status of trial NCT05978804?
This trial is currently terminated. It is a NA study. The enrollment target is 36 participants. The study started on 2023-08-10. Estimated completion is 2025-09-10.
What interventions are being tested in trial NCT05978804?
The interventions under investigation include: Computerized Cognitive Training (OTHER), Active tDCS (tDCS) on DLPFC (DEVICE).
Who is sponsoring clinical trial NCT05978804?
This trial is sponsored by Johns Hopkins University, which has 1,448 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05978804's enrollment target sits among peer trials
36 1541st of 2000 higher than 437 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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