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NCT05961189 · ClinicalTrials.gov registry record · Early Phase 1
Influence of Short-Term Antibiotic Therapy on Exercise
A Early Phase 1 study of Exercise and Gastrointestinal Microbiome, sponsored by Rutgers, The State University of New Jersey.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 40
- Enrollment target
- 2
- Study locations
NCT05961189: Recruiting Early Phase 1 study of Exercise and Gastrointestinal Microbiome, sponsored by Rutgers, The State University of New Jersey.
NCT05961189 is a Early Phase 1 study of Exercise and Gastrointestinal Microbiome that is actively recruiting participants, run by Rutgers, The State University of New Jersey. The registered enrollment target is 40 participants, below the 8,910-participant average among 57 other Exercise trials with a reported enrollment target (100% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05961189, a Early Phase 1 study of Exercise and Gastrointestinal Microbiome, is actively recruiting participants, sponsored by Rutgers, The State University of New Jersey.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 40 participants
- Enrollment target
- 2
- Study locations
Study Summary
The gut microbiome refers to the trillions of bacteria that inhabit the stomach and other regions involved in the digestion of food, including the intestines. Compelling studies of animals (rodents) suggest that the health of the gut microbiome may influence skeletal muscle function and exercise performance. To date, there have been no similar observations reported in humans. A common experimental approach in animal studies to temporarily disrupt the gut microbiome is through the use of antibiotic therapies. Azithromycin is an antibiotic medicine prescribed to humans for the treatment of mild to moderate infections caused by bacteria. The purpose of the proposed project is to determine the influence of short-term (5-days) antibiotic therapy (azithromycin) on exercise performance in young, healthy adults. Treadmill exercise performance will be compared in two groups of adults before and after 5-days ingestion of azithromycin, or a placebo (something that has no physical effect).
Primary Outcome
Maximal oxygen consumption treadmill test to determine overall aerobic fitness
Conditions Studied
Interventions
- DRUG Azithromycin
Study Locations (2)
Colorado
- Human Performance Clinical Research Lab - Fort Collins
New Jersey
- Nutrition, and Exercise Metabolism Lab - New Brunswick
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2023-09-01 |
| Est. Completion | 2025-12-01 |
| Phase | Early Phase 1 |
What NCT05961189 shows while recruiting
NCT05961189 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 8,910-participant average among 57 other Exercise trials with a reported enrollment target (100% lower).
The record links to 2 conditions, with Exercise appearing as the primary indexed condition, and to 1 intervention - of which Azithromycin is the first listed.
NCT05961189 reports a single indexed study location in Colorado, New Jersey.
Frequently Asked Questions
What is clinical trial NCT05961189 about?
NCT05961189 is a clinical study titled "Influence of Short-Term Antibiotic Therapy on Exercise". The gut microbiome refers to the trillions of bacteria that inhabit the stomach and other regions involved in the digestion of food, including the intestines. Compelling studies of animals (rodents) suggest that the health of the gut microbiome may influence skeletal muscle function and exercise per...
What is the current status of trial NCT05961189?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 40 participants. The study started on 2023-09-01. Estimated completion is 2025-12-01.
What conditions does trial NCT05961189 study?
This clinical trial studies the following conditions: Exercise, Gastrointestinal Microbiome.
What interventions are being tested in trial NCT05961189?
The interventions under investigation include: Azithromycin (DRUG).
Who is sponsoring clinical trial NCT05961189?
This trial is sponsored by Rutgers, The State University of New Jersey, which has 413 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05961189 being conducted?
This trial has 2 study locations across Colorado, New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Exercise
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05961189's enrollment target sits among peer trials
40 35th of 57 higher than 18 of 57 other Exercise trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Exercise trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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