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NCT05924503 · ClinicalTrials.gov registry record
BRAIN-HEART Ultrasound Study Normative Values for Transcranial Doppler Based Cerebral Blood Flow Assessment
A clinical trial of Mechanical Circulatory Support, sponsored by Wake Forest University Health Sciences.
- Recruiting
- Registry status
- 1,000
- Enrollment target
- 1
- Study location
NCT05924503: Recruiting study of Mechanical Circulatory Support, sponsored by Wake Forest University Health Sciences.
NCT05924503 is a study of Mechanical Circulatory Support that is actively recruiting participants, run by Wake Forest University Health Sciences. The registered enrollment target is 1,000 participants. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05924503, a study of Mechanical Circulatory Support, is actively recruiting participants, sponsored by Wake Forest University Health Sciences.
- RECRUITING
- Registry status
- 1,000 participants
- Enrollment target
- 1
- Study location
Study Summary
There is a dire need to establish normative values for transcranial Doppler(TCD) derived cerebral blood flow parameters for each type of Mechanical circulatory support (MCS) device and explore the relationship between the MCS device's systemic flow dynamics and TCD based cerebral flow(CBF) parameters TCD derived cerebral blood flow parameters can then be investigated as targets used to titrate systemic flow dynamics from MCS. Having target flow rates titrated to patient specific condition using TCD may help avoid both hypoperfusion as well as the possibility of hyperemia reperfusion injury contributing to neurological morbidity. We propose a multicenter study to gather normative data on TCD derived CBF and MCS systemic dynamics for a wide range of patient demographics. Such data collection is only possible with multi-center collaboration given the small volume of patients with MCS patients in each center.
Primary Outcome
Normal mean velocity of the intracranial blood vessels (Middle cerebral artery (MCA), Internal carotid artery (ICA) Posterior Cerebral Arteries (PCA), Anterior Cerebral Artery (ACA), Basilar and Vertebral A )is usually \< 80 cm/s in patients with normal cardiac output. We will explore the range of normal values of intracranial vessel velocity in patients with different degree/ type of MCS devices adjusted to the contribution of LV to blood flow 0-10 L/min
Conditions Studied
Study Locations (1)
North Carolina
- Wake Forest University Health Sciences - Winston-Salem
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,000 participants |
| Start Date | 2024-05-22 |
| Est. Completion | 2026-06 |
What NCT05924503 shows while recruiting
NCT05924503 is an observational study that tracks outcomes without assigning an intervention. Its 1,000 participants enrollment target places it among the larger protocols in the corpus.
The record links to 1 condition, with Mechanical Circulatory Support appearing as the primary indexed condition, and to 0 interventions.
NCT05924503 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT05924503 about?
NCT05924503 is a clinical study titled "BRAIN-HEART Ultrasound Study Normative Values for Transcranial Doppler Based Cerebral Blood Flow Assessment". There is a dire need to establish normative values for transcranial Doppler(TCD) derived cerebral blood flow parameters for each type of Mechanical circulatory support (MCS) device and explore the relationship between the MCS device's systemic flow dynamics and TCD based cerebral flow(CBF) parameter...
What is the current status of trial NCT05924503?
This trial is currently recruiting. The enrollment target is 1,000 participants. The study started on 2024-05-22. Estimated completion is 2026-06.
What conditions does trial NCT05924503 study?
This clinical trial studies the following conditions: Mechanical Circulatory Support.
Who is sponsoring clinical trial NCT05924503?
This trial is sponsored by Wake Forest University Health Sciences, which has 1,140 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05924503 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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