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NCT05877885 · ClinicalTrials.gov registry record · NA
Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics
A NA study of Major Depressive Disorder and Apathy, sponsored by AdventHealth.
- Recruiting
- Registry status
- NA
- Development phase
- 84
- Enrollment target
- 1
- Study location
NCT05877885: Recruiting NA study of Major Depressive Disorder and Apathy, sponsored by AdventHealth.
NCT05877885 is a NA study of Major Depressive Disorder and Apathy that is actively recruiting participants, run by AdventHealth. The registered enrollment target is 84 participants, below the 377-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (78% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05877885, a NA study of Major Depressive Disorder and Apathy, is actively recruiting participants, sponsored by AdventHealth.
- RECRUITING
- Registry status
- NA
- Development phase
- 84 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this randomized controlled trial is to evaluate the potential of a customized digital cognitive training intervention to target aspects of brain function in apathy of late-life depression and reduce symptoms of apathy and related cognitive and behavioral deficits. The investigators hypothesize that 4 weeks of a customized digital cognitive training program will lead to changes in brain connectivity, apathy severity, and cognitive control performance.
Primary Outcome
Calculated from resting state fMRI scan. Validation of target engagement.
Conditions Studied
Interventions
- BEHAVIORAL Targeted Cognitive Training Intervention
- BEHAVIORAL General Cognitive Training Intervention
Study Locations (1)
Florida
- AdventHealth Neuroscience Institute - Orlando
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 84 participants |
| Start Date | 2025-09-19 |
| Est. Completion | 2028-12-01 |
| Phase | NA |
What NCT05877885 shows while recruiting
NCT05877885 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 84 participants, a relatively small participant target, below the 377-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (78% lower).
The record links to 2 conditions, with Major Depressive Disorder appearing as the primary indexed condition, and to 2 interventions - of which Targeted Cognitive Training Intervention is the first listed.
NCT05877885 reports a single indexed study location in Florida.
Frequently Asked Questions
What is clinical trial NCT05877885 about?
NCT05877885 is a clinical study titled "Targeting Network Dysfunction in Apathy of Late-life Depression Using Digital Therapeutics". The goal of this randomized controlled trial is to evaluate the potential of a customized digital cognitive training intervention to target aspects of brain function in apathy of late-life depression and reduce symptoms of apathy and related cognitive and behavioral deficits. The investigators hypot...
What is the current status of trial NCT05877885?
This trial is currently recruiting. It is a NA study. The enrollment target is 84 participants. The study started on 2025-09-19. Estimated completion is 2028-12-01.
What conditions does trial NCT05877885 study?
This clinical trial studies the following conditions: Major Depressive Disorder, Apathy.
What interventions are being tested in trial NCT05877885?
The interventions under investigation include: Targeted Cognitive Training Intervention (BEHAVIORAL), General Cognitive Training Intervention (BEHAVIORAL).
Who is sponsoring clinical trial NCT05877885?
This trial is sponsored by AdventHealth, which has 95 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05877885 being conducted?
This trial has 1 study location across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Major Depressive Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05877885's enrollment target sits among peer trials
84 141st of 282 higher than 142 of 282 other Major Depressive Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Major Depressive Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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