Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05853068 · ClinicalTrials.gov registry record
Assessment of PaO2/FiO2 Ratio Pre and POst INTubation
A clinical trial of Acute Hypoxemic Respiratory Failure, sponsored by Dr. Negrin University Hospital.
- Active
- Registry status
- 400
- Enrollment target
- 2
- Study locations
NCT05853068: Active study of Acute Hypoxemic Respiratory Failure, sponsored by Dr. Negrin University Hospital.
NCT05853068 is a study of Acute Hypoxemic Respiratory Failure that is active but no longer recruiting, run by Dr. Negrin University Hospital. The registered enrollment target is 400 participants, below the 891-participant average among 5 other Acute Hypoxemic Respiratory Failure trials with a reported enrollment target (55% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05853068, a study of Acute Hypoxemic Respiratory Failure, is active but no longer recruiting, sponsored by Dr. Negrin University Hospital.
- ACTIVE NOT RECRUITING
- Registry status
- 400 participants
- Enrollment target
- 2
- Study locations
Study Summary
We designed this study to dtermine whether invasive mechanical ventilation (MV) would have an impact on the reclassification of patients with acute hypoxemic respiratory failure (AHRF) -treated previously with non-invasive respiratory support- into categories of severity (mild, moderate, and severe). Our hypothesis is that the assessment of PaO2/FiO2 ratio on PEEP greater or equal to 5 cmH2O after intubation, in patients labeled as mild/moderate/severe AHRF while on non-invasive respiratory support, would identify that a marked proportion of patients would change the degree of severity after a brief period of invasive MV
Primary Outcome
from severe/moderate to moderate/mild, from moderate/mild to mild after a brief period of invasive MV
Conditions Studied
Interventions
- DEVICE Mechanical ventilation
Study Locations (2)
Illinois
- Rush University Medical Center - Chicago
Las Palmas
- Jesús Villar - Las Palmas de Gran Canaria
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 400 participants |
| Start Date | 2023-04-29 |
| Est. Completion | 2025-11-30 |
What the registry record for NCT05853068 still lists
NCT05853068 is an observational study that tracks outcomes without assigning an intervention. The registered 400 participants enrollment target is mid-sized for trials with a published cap, below the 891-participant average among 5 other Acute Hypoxemic Respiratory Failure trials with a reported enrollment target (55% lower).
The record links to 1 condition, with Acute Hypoxemic Respiratory Failure appearing as the primary indexed condition, and to 1 intervention - of which Mechanical ventilation is the first listed.
NCT05853068 reports a single indexed study location in Illinois, Las Palmas.
Frequently Asked Questions
What is clinical trial NCT05853068 about?
NCT05853068 is a clinical study titled "Assessment of PaO2/FiO2 Ratio Pre and POst INTubation". We designed this study to dtermine whether invasive mechanical ventilation (MV) would have an impact on the reclassification of patients with acute hypoxemic respiratory failure (AHRF) -treated previously with non-invasive respiratory support- into categories of severity (mild, moderate, and severe)...
What is the current status of trial NCT05853068?
This trial is currently active not recruiting. The enrollment target is 400 participants. The study started on 2023-04-29. Estimated completion is 2025-11-30.
What conditions does trial NCT05853068 study?
This clinical trial studies the following conditions: Acute Hypoxemic Respiratory Failure.
What interventions are being tested in trial NCT05853068?
The interventions under investigation include: Mechanical ventilation (DEVICE).
Who is sponsoring clinical trial NCT05853068?
This trial is sponsored by Dr. Negrin University Hospital, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05853068 being conducted?
This trial has 2 study locations across Illinois, Las Palmas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Acute Hypoxemic Respiratory Failure
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
-
The Effects of Music Therapy on Adult Patients Requiring Mechanical Ventilation in the ICU
RECRUITING · NA
-
Physiological Effects of Continuous Negative External Pressure for Acute Hypoxemic Respiratory Failure
RECRUITING · NA
-
ROX Index for the Timing of Intubation in Nasal High Flow
RECRUITING · NA
-
Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients
RECRUITING · NA
-
Strategies for Anticoagulation During Venovenous ECMO
COMPLETED · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01665326 · 400 participants
Determination of CRIM Status and Longitudinal Follow-up of Individuals With Pompe Disease
- NCT02108054 · 400 participants · NA
Behavioral and Functional Task Development, Implementation, and Testing
- NCT02216500 · 400 participants · NA
Ketogenic Therapy Effects on Electrical and Metabolic Abnormalities in Epilepsy
- NCT02250352 · 400 participants
Core Biopsies for Establishing a Breast Tumor Tissue Repository
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI