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NCT05675345 · ClinicalTrials.gov registry record · NA
Physiological Effects of Continuous Negative External Pressure for Acute Hypoxemic Respiratory Failure
A NA study of Acute Hypoxemic Respiratory Failure, sponsored by Columbia University.
- Recruiting
- Registry status
- NA
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT05675345: Recruiting NA study of Acute Hypoxemic Respiratory Failure, sponsored by Columbia University.
NCT05675345 is a NA study of Acute Hypoxemic Respiratory Failure that is actively recruiting participants, run by Columbia University. The registered enrollment target is 20 participants, below the 967-participant average among 5 other Acute Hypoxemic Respiratory Failure trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05675345, a NA study of Acute Hypoxemic Respiratory Failure, is actively recruiting participants, sponsored by Columbia University.
- RECRUITING
- Registry status
- NA
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
This study is being conducted to evaluate if wearing a non-invasive breathing support device over the chest/abdomen improves markers of breathing in patients with lung injury requiring high-flow oxygen. The breathing support device consists of a plastic shell that sits over the chest and abdomen and connects to a vacuum that helps the chest expand with breathing. This breathing support is known as continuous negative external pressure (CNEP). Study findings will help determine if this breathing support device might be useful for patients with acute hypoxemic respiratory failure (AHRF).
Primary Outcome
The change in SpO2/FiO2 within each participant as measured at baseline and at the end of each treatment assignment period. The average SpO2/FiO2 over the last five minutes of the treatment period will be used.
Conditions Studied
Interventions
- DEVICE HFNC only
- DEVICE HFNC + CNEP10
- DEVICE HFNC + CNEP20
- DEVICE HFNC + CNEP30
Study Locations (1)
New York
- Columbia University Irving Medical Center - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2024-02-28 |
| Est. Completion | 2026-12-31 |
| Phase | NA |
What NCT05675345 shows while recruiting
NCT05675345 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 967-participant average among 5 other Acute Hypoxemic Respiratory Failure trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Acute Hypoxemic Respiratory Failure appearing as the primary indexed condition, and to 4 interventions - of which HFNC only is the first listed.
NCT05675345 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT05675345 about?
NCT05675345 is a clinical study titled "Physiological Effects of Continuous Negative External Pressure for Acute Hypoxemic Respiratory Failure". This study is being conducted to evaluate if wearing a non-invasive breathing support device over the chest/abdomen improves markers of breathing in patients with lung injury requiring high-flow oxygen. The breathing support device consists of a plastic shell that sits over the chest and abdomen and...
What is the current status of trial NCT05675345?
This trial is currently recruiting. It is a NA study. The enrollment target is 20 participants. The study started on 2024-02-28. Estimated completion is 2026-12-31.
What conditions does trial NCT05675345 study?
This clinical trial studies the following conditions: Acute Hypoxemic Respiratory Failure.
What interventions are being tested in trial NCT05675345?
The interventions under investigation include: HFNC only (DEVICE), HFNC + CNEP10 (DEVICE), HFNC + CNEP20 (DEVICE), HFNC + CNEP30 (DEVICE).
Who is sponsoring clinical trial NCT05675345?
This trial is sponsored by Columbia University, which has 958 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05675345 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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