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NCT05785845 · ClinicalTrials.gov registry record · NA
Computed Tomography-Guided Stereotactic Adaptive Radiotherapy (CT-STAR) for the Treatment of Central and Ultra-Central Early-Stage Non-Small Cell Lung Cancer
A NA study of Non-Small Cell Lung Cancer and Early Stage Non-Small Cell Lung Cancer, sponsored by Washington University School of Medicine.
- Active
- Registry status
- NA
- Development phase
- 17
- Enrollment target
- 1
- Study location
NCT05785845: Active NA study of Non-Small Cell Lung Cancer and Early Stage Non-Small Cell Lung Cancer, sponsored by Washington University School of Medicine.
NCT05785845 is a NA study of Non-Small Cell Lung Cancer and Early Stage Non-Small Cell Lung Cancer that is active but no longer recruiting, run by Washington University School of Medicine. The registered enrollment target is 17 participants, below the 652-participant average among 454 other Non-Small Cell Lung Cancer trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05785845, a NA study of Non-Small Cell Lung Cancer and Early Stage Non-Small Cell Lung Cancer, is active but no longer recruiting, sponsored by Washington University School of Medicine.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 17 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will evaluate the impact of CT-guided adaptive stereotactic radiotherapy (CT-STAR) to central and ultra-central early-stage non-small cell lung cancers on grade 3 or greater toxicity. Online adaptive radiation therapy was until recently only done clinically on an integrated MRI-guided system, but recently, Varian Medical Systems has created a CT-guided radiotherapy machine capable of online adaptive radiotherapy (ETHOS). The vast majority of stereotactic body radiotherapy (SBRT) for early-stage lung cancers is performed on a CT-guided machine rather than an MRI-guided machine, necessitating the evaluation of adaptive radiotherapy using ETHOS in this population. Historically, the non-adaptive, stereotactic treatment of central and ultra-central thoracic disease has been associated with unacceptable rates of grade 3+ toxicity. This has resulted in widespread adoption of a hypofractionated, less ablative 8-15 day treatment courses, with a baseline, one-year grade 3+ toxicity rate of 20%. Use of CT-STAR with daily, CT-guided plan adaptation to carefully spare adjacent organs-at-risk (OAR) in this setting may enable safe delivery of a shorter (5 fraction) and more ablative radiotherapy course.
Primary Outcome
-Toxicity graded per CTCAE version 5.
Conditions Studied
Interventions
- RADIATION Computed tomography-guided stereotactic adaptive radiotherapy
- DEVICE ETHOS
Study Locations (1)
Missouri
- Washington University School of Medicine - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 17 participants |
| Start Date | 2023-04-10 |
| Est. Completion | 2026-07-28 |
| Phase | NA |
What the registry record for NCT05785845 still lists
NCT05785845 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 17 participants, a relatively small participant target, below the 652-participant average among 454 other Non-Small Cell Lung Cancer trials with a reported enrollment target (97% lower).
The record links to 2 conditions, with Non-Small Cell Lung Cancer appearing as the primary indexed condition, and to 2 interventions - of which Computed tomography-guided stereotactic adaptive radiotherapy is the first listed.
NCT05785845 reports a single indexed study location in Missouri.
Frequently Asked Questions
What is clinical trial NCT05785845 about?
NCT05785845 is a clinical study titled "Computed Tomography-Guided Stereotactic Adaptive Radiotherapy (CT-STAR) for the Treatment of Central and Ultra-Central Early-Stage Non-Small Cell Lung Cancer". This study will evaluate the impact of CT-guided adaptive stereotactic radiotherapy (CT-STAR) to central and ultra-central early-stage non-small cell lung cancers on grade 3 or greater toxicity. Online adaptive radiation therapy was until recently only done clinically on an integrated MRI-guided sys...
What is the current status of trial NCT05785845?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 17 participants. The study started on 2023-04-10. Estimated completion is 2026-07-28.
What conditions does trial NCT05785845 study?
This clinical trial studies the following conditions: Non-Small Cell Lung Cancer, Early Stage Non-Small Cell Lung Cancer.
What interventions are being tested in trial NCT05785845?
The interventions under investigation include: Computed tomography-guided stereotactic adaptive radiotherapy (RADIATION), ETHOS (DEVICE).
Who is sponsoring clinical trial NCT05785845?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05785845 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05785845's enrollment target sits among peer trials
17 428th of 454 higher than 27 of 454 other Non-Small Cell Lung Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Non-Small Cell Lung Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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