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NCT05740566 · ClinicalTrials.gov registry record · Phase 3
Study Comparing Tarlatamab With Standard of Care Chemotherapy in Relapsed Small Cell Lung Cancer
A Phase 3 study of Small Cell Lung Cancer (SCLC), sponsored by Amgen.
- Active
- Registry status
- Phase 3
- Development phase
- 509
- Enrollment target
- 20
- Study locations
NCT05740566: Active Phase 3 study of Small Cell Lung Cancer (SCLC), sponsored by Amgen.
NCT05740566 is a Phase 3 study of Small Cell Lung Cancer (SCLC) that is active but no longer recruiting, run by Amgen. The registered enrollment target is 509 participants, above the 252-participant average among 12 other Small Cell Lung Cancer (SCLC) trials with a reported enrollment target (102% higher). The trial reports 20 study locations across 16 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05740566, a Phase 3 study of Small Cell Lung Cancer (SCLC), is active but no longer recruiting, sponsored by Amgen.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 3
- Development phase
- 509 participants
- Enrollment target
- 20
- Study locations
Study Summary
The main objective is to compare the efficacy of tarlatamab with standard of care (SOC) on prolonging overall survival (OS).
Primary Outcome
OS was defined as time from randomization until death from any cause. Median overall survival was estimated using Kaplan-Meier method. 95% confidence intervals (CIs) were calculated using the Brookmeyer and Crowley method.
Conditions Studied
Interventions
- DRUG Topotecan
- DRUG Lurbinectedin
- DRUG Tarlatamab
- DRUG Amrubicin
Study Locations (20)
New York
- New York University Grossman School of Medicine and New York University Langone Hospitals - New York
- Perlmutter Cancer Center at New York University Langone Hospital----Long Island - New York
- Memorial Sloan Kettering Cancer Center - New York
- Northport Veterans Affairs Medical Center - Northport
Illinois
- Northwestern University - Chicago
- University of Illinois Chicago - Chicago
Alabama
- University of South Alabama Mitchell Cancer Institute - Mobile
Alaska
- Alaska Oncology and Hematology - Anchorage
Arkansas
- University of Arkansas for Medical Sciences - Little Rock
California
- University of California Los Angeles - Santa Monica
Indiana
- Indiana University - Indianapolis
Iowa
- University of Iowa - Iowa City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 509 participants |
| Start Date | 2023-05-31 |
| Est. Completion | 2028-03-26 |
| Phase | Phase 3 |
What the registry record for NCT05740566 still lists
NCT05740566 is an interventional study that assigns participants to a tested intervention. The registered 509 participants enrollment target is mid-sized for trials with a published cap, above the 252-participant average among 12 other Small Cell Lung Cancer (SCLC) trials with a reported enrollment target (102% higher).
The record links to 1 condition, with Small Cell Lung Cancer (SCLC) appearing as the primary indexed condition, and to 4 interventions - of which Topotecan is the first listed.
NCT05740566 names 20 study sites across 16 states, led by New York, Illinois, Alabama.
Frequently Asked Questions
What is clinical trial NCT05740566 about?
NCT05740566 is a clinical study titled "Study Comparing Tarlatamab With Standard of Care Chemotherapy in Relapsed Small Cell Lung Cancer". The main objective is to compare the efficacy of tarlatamab with standard of care (SOC) on prolonging overall survival (OS).
What is the current status of trial NCT05740566?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 509 participants. The study started on 2023-05-31. Estimated completion is 2028-03-26.
What conditions does trial NCT05740566 study?
This clinical trial studies the following conditions: Small Cell Lung Cancer (SCLC).
What interventions are being tested in trial NCT05740566?
The interventions under investigation include: Topotecan (DRUG), Lurbinectedin (DRUG), Tarlatamab (DRUG), Amrubicin (DRUG).
Who is sponsoring clinical trial NCT05740566?
This trial is sponsored by Amgen, which has 558 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05740566 being conducted?
This trial has 20 study locations across Alabama, Alaska, Arkansas, California, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Small Cell Lung Cancer (SCLC)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05740566's enrollment target sits among peer trials
509 3rd of 12 higher than 10 of 12 other Small Cell Lung Cancer (SCLC) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Small Cell Lung Cancer (SCLC) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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