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NCT05708274 · ClinicalTrials.gov registry record · Phase 1
Pharmacological Agents for Chronic Spinal Cord Injury (SCI)
A Phase 1 study of Spinal Cord Injuries, sponsored by Bronx VA Medical Center.
- Completed
- Registry status
- Phase 1
- Development phase
- 25
- Enrollment target
- 1
- Study location
NCT05708274: Completed Phase 1 study of Spinal Cord Injuries, sponsored by Bronx VA Medical Center.
NCT05708274 is a Phase 1 study of Spinal Cord Injuries that has completed, run by Bronx VA Medical Center. The registered enrollment target is 25 participants, below the 61-participant average among 202 other Spinal Cord Injuries trials with a reported enrollment target (59% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05708274, a Phase 1 study of Spinal Cord Injuries, has completed, sponsored by Bronx VA Medical Center.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 25 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to investigate the short-term effects of 3 approved FDA drugs (cyproheptadine (CPH), carbidopa-levodopa (CD-LD), and atomoxetine (ATX)) on motor responses when delivered in combination with hand training exercises in people with chronic spinal cord injury. The goal is to learn how to better strengthen connections between the brain and spinal cord after spinal cord injury, and if this connection is improved by one(or more) of the drugs. Multiple aspects of nerve transmission and muscle response will be measured via noninvasive brain and spinal cord stimulation, along with motor performance (dexterity and strength).
Primary Outcome
Unilateral manual dexterity will be assessed using the 9-Hole Peg Test (Aim 1a).
Conditions Studied
Interventions
- DRUG CPH + hand training
- DRUG CD-LD + hand training
- DRUG ATX + hand training
- DRUG Placebo + hand training
Study Locations (1)
New York
- James J. Peters Veterans Affairs Medical Center - The Bronx
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 25 participants |
| Start Date | 2023-01-20 |
| Est. Completion | 2025-10-30 |
| Phase | Phase 1 |
What the finished NCT05708274 record still lists
NCT05708274 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 25 participants, a relatively small participant target, below the 61-participant average among 202 other Spinal Cord Injuries trials with a reported enrollment target (59% lower).
The record links to 1 condition, with Spinal Cord Injuries appearing as the primary indexed condition, and to 4 interventions - of which CPH + hand training is the first listed.
NCT05708274 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT05708274 about?
NCT05708274 is a clinical study titled "Pharmacological Agents for Chronic Spinal Cord Injury (SCI)". The purpose of this study is to investigate the short-term effects of 3 approved FDA drugs (cyproheptadine (CPH), carbidopa-levodopa (CD-LD), and atomoxetine (ATX)) on motor responses when delivered in combination with hand training exercises in people with chronic spinal cord injury. The goal is to...
What is the current status of trial NCT05708274?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 25 participants. The study started on 2023-01-20. Estimated completion is 2025-10-30.
What conditions does trial NCT05708274 study?
This clinical trial studies the following conditions: Spinal Cord Injuries.
What interventions are being tested in trial NCT05708274?
The interventions under investigation include: CPH + hand training (DRUG), CD-LD + hand training (DRUG), ATX + hand training (DRUG), Placebo + hand training (DRUG).
Who is sponsoring clinical trial NCT05708274?
This trial is sponsored by Bronx VA Medical Center, which has 13 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05708274 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Spinal Cord Injuries
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05708274's enrollment target sits among peer trials
25 110th of 202 higher than 90 of 202 other Spinal Cord Injuries trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Spinal Cord Injuries trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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