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NCT05593549 · ClinicalTrials.gov registry record · Early Phase 1
Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction
A Early Phase 1 study of Type 2 Diabetes and Healthy Aging, sponsored by Medical College of Wisconsin.
- Recruiting
- Registry status
- Early Phase 1
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT05593549: Recruiting Early Phase 1 study of Type 2 Diabetes and Healthy Aging, sponsored by Medical College of Wisconsin.
NCT05593549 is a Early Phase 1 study of Type 2 Diabetes and Healthy Aging that is actively recruiting participants, run by Medical College of Wisconsin. The registered enrollment target is 60 participants, below the 3,923-participant average among 327 other Type 2 Diabetes trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05593549, a Early Phase 1 study of Type 2 Diabetes and Healthy Aging, is actively recruiting participants, sponsored by Medical College of Wisconsin.
- RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this clinical trial is to examine the role of autophagy on microvascular function in adults with Type 2 Diabetes. The main question it aims to answer are: * Does presence of Type 2 Diabetes reduce autophagy and impair microvascular function? * Does exposure to high glucose impair autophagy and subsequently microvascular function? Participants will undergo 2 study days. The primary outcome will be in vivo microvascular function testing. Following the first study day participants will undergo either supplementation with trehalose, an autophagy activator, or placebo for 14 days. The second study day will test in vivo microvascular function.
Primary Outcome
Cutaneous microvascular function measured via laser Doppler flowmetry coupled with intradermal microdialysis of non-specific nitric oxide synthase inhibitor, L-NAME
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Trehalose
Study Locations (1)
Wisconsin
- Medical College of Wisconsin - Milwaukee
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2023-01-01 |
| Est. Completion | 2029-12-31 |
| Phase | Early Phase 1 |
What NCT05593549 shows while recruiting
NCT05593549 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 3,923-participant average among 327 other Type 2 Diabetes trials with a reported enrollment target (98% lower).
The record links to 2 conditions, with Type 2 Diabetes appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT05593549 reports a single indexed study location in Wisconsin.
Frequently Asked Questions
What is clinical trial NCT05593549 about?
NCT05593549 is a clinical study titled "Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction". The goal of this clinical trial is to examine the role of autophagy on microvascular function in adults with Type 2 Diabetes. The main question it aims to answer are: * Does presence of Type 2 Diabetes reduce autophagy and impair microvascular function? * Does exposure to high glucose impair autoph...
What is the current status of trial NCT05593549?
This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 60 participants. The study started on 2023-01-01. Estimated completion is 2029-12-31.
What conditions does trial NCT05593549 study?
This clinical trial studies the following conditions: Type 2 Diabetes, Healthy Aging.
What interventions are being tested in trial NCT05593549?
The interventions under investigation include: Placebo (DRUG), Trehalose (DRUG).
Who is sponsoring clinical trial NCT05593549?
This trial is sponsored by Medical College of Wisconsin, which has 447 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05593549 being conducted?
This trial has 1 study location across Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Type 2 Diabetes
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05593549's enrollment target sits among peer trials
60 192nd of 327 higher than 124 of 327 other Type 2 Diabetes trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Type 2 Diabetes trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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