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NCT05593549 · ClinicalTrials.gov registry record · Early Phase 1

Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction

A Early Phase 1 study of Type 2 Diabetes and Healthy Aging, sponsored by Medical College of Wisconsin.

Recruiting
Registry status
Early Phase 1
Development phase
60
Enrollment target
1
Study location

NCT05593549 is a Early Phase 1 study of Type 2 Diabetes and Healthy Aging that is actively recruiting participants, run by Medical College of Wisconsin. The registered enrollment target is 60 participants, below the 1,102-participant average among 288 other Type 2 Diabetes trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT05593549, a Early Phase 1 study of Type 2 Diabetes and Healthy Aging, is actively recruiting participants, sponsored by Medical College of Wisconsin.

RECRUITING
Registry status
Early Phase 1
Development phase
60 participants
Enrollment target
1
Study location

Study Summary

The goal of this clinical trial is to examine the role of autophagy on microvascular function in adults with Type 2 Diabetes. The main question it aims to answer are: * Does presence of Type 2 Diabetes reduce autophagy and impair microvascular function? * Does exposure to high glucose impair autophagy and subsequently microvascular function? Participants will undergo 2 study days. The primary outcome will be in vivo microvascular function testing. Following the first study day participants will undergo either supplementation with trehalose, an autophagy activator, or placebo for 14 days. The second study day will test in vivo microvascular function.

Conditions Studied

Type 2 Diabetes Healthy Aging

Interventions

  • DRUG Placebo
  • DRUG Trehalose

Study Locations (1)

Wisconsin

  • Medical College of Wisconsin - Milwaukee

Trial Details

FieldValue
Enrollment Target 60 participants
Start Date 2023-01-01
Est. Completion 2029-12-31
Phase Early Phase 1

Sponsor

Medical College of Wisconsin

447 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05593549

The ClinicalTrials.gov registry entry for NCT05593549 describes a study currently listed as recruiting, categorized as Early Phase 1. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,102-participant average among 288 other Type 2 Diabetes trials with a reported enrollment target (95% lower). The listed sponsor is Medical College of Wisconsin, which has 447 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Type 2 Diabetes appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.

NCT05593549 reports 1 study location spanning 1 distinct geographic area - top geographies include Wisconsin.

Frequently Asked Questions

What is clinical trial NCT05593549 about?

NCT05593549 is a clinical study titled "Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction". The goal of this clinical trial is to examine the role of autophagy on microvascular function in adults with Type 2 Diabetes. The main question it aims to answer are: * Does presence of Type 2 Diabetes reduce autophagy and impair microvascular function? * Does exposure to high glucose impair autoph...

What is the current status of trial NCT05593549?

This trial is currently recruiting. It is a Early Phase 1 study. The enrollment target is 60 participants. The study started on 2023-01-01. Estimated completion is 2029-12-31.

What conditions does trial NCT05593549 study?

This clinical trial studies the following conditions: Type 2 Diabetes, Healthy Aging.

What interventions are being tested in trial NCT05593549?

The interventions under investigation include: Placebo (DRUG), Trehalose (DRUG).

Who is sponsoring clinical trial NCT05593549?

This trial is sponsored by Medical College of Wisconsin, which has 447 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05593549 being conducted?

This trial has 1 study location across Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.