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NCT05480722 · ClinicalTrials.gov registry record · NA
Central Sodium Sensing: Implications for Blood Pressure Regulation
A NA study of Salt-Sensitivity of Blood Pressure, sponsored by University of Delaware.
- Completed
- Registry status
- NA
- Development phase
- 29
- Enrollment target
- 1
- Study location
NCT05480722: Completed NA study of Salt-Sensitivity of Blood Pressure, sponsored by University of Delaware.
NCT05480722 is a NA study of Salt-Sensitivity of Blood Pressure that has completed, run by University of Delaware. The registered enrollment target is 29 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05480722, a NA study of Salt-Sensitivity of Blood Pressure, has completed, sponsored by University of Delaware.
- COMPLETED
- Registry status
- NA
- Development phase
- 29 participants
- Enrollment target
- 1
- Study location
Study Summary
The ability of the brain to sense changing sodium levels in the blood is critical in mediating the neurohumoral responses to hypernatremia, however, the mechanisms underlying sodium sensing in humans is poorly understood. The purpose of this study is to identify key sodium-sensing regions of the human brain in older adults and determine if the Na-K-2Cl co-transporter mediates the neurohumoral response to acute hypernatremia. Completion of this project will increase our understanding of blood pressure regulation, which has major public health implications.
Primary Outcome
Functional connectivity between sodium sensing circumventricular organs (subfornical organ (SFO) and organum vasculosum of the lamina terminalis(OVLT)) was calculated (expressed as the z-score). Functional connectivity is a measure of the the correlation (or synchronization) of the blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) signal time course between two brain regions. Pearson correlations were computed between the BOLD fMRI signal in the SFO and OVLT in a s
Conditions Studied
Interventions
- OTHER Hypertonic Saline with furosemide
- OTHER Hypertonic Saline without furosemide
Study Locations (1)
Delaware
- William B Farquhar - Newark
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 29 participants |
| Start Date | 2022-06-01 |
| Est. Completion | 2025-01-31 |
| Phase | NA |
What the finished NCT05480722 record still lists
NCT05480722 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 29 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Salt-Sensitivity of Blood Pressure appearing as the primary indexed condition, and to 2 interventions - of which Hypertonic Saline with furosemide is the first listed.
NCT05480722 reports a single indexed study location in Delaware.
Frequently Asked Questions
What is clinical trial NCT05480722 about?
NCT05480722 is a clinical study titled "Central Sodium Sensing: Implications for Blood Pressure Regulation". The ability of the brain to sense changing sodium levels in the blood is critical in mediating the neurohumoral responses to hypernatremia, however, the mechanisms underlying sodium sensing in humans is poorly understood. The purpose of this study is to identify key sodium-sensing regions of the hum...
What is the current status of trial NCT05480722?
This trial is currently completed. It is a NA study. The enrollment target is 29 participants. The study started on 2022-06-01. Estimated completion is 2025-01-31.
What conditions does trial NCT05480722 study?
This clinical trial studies the following conditions: Salt-Sensitivity of Blood Pressure.
What interventions are being tested in trial NCT05480722?
The interventions under investigation include: Hypertonic Saline with furosemide (OTHER), Hypertonic Saline without furosemide (OTHER).
Who is sponsoring clinical trial NCT05480722?
This trial is sponsored by University of Delaware, which has 106 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05480722 being conducted?
This trial has 1 study location across Delaware. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Where NCT05480722's enrollment target sits among peer trials
29 1702nd of 2000 higher than 297 of 2,000 other NA trials
participants (enrollment target), bucketed by value
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Source ClinicalTrials.gov registry export · 2026-08-08
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