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NCT05424783 · ClinicalTrials.gov registry record
MRI And GPS Informing Choices for Prostate Cancer Treatment (MAGIC)
A clinical trial of Prostate Cancer, sponsored by Northwestern University.
- Recruiting
- Registry status
- 222
- Enrollment target
- 2
- Study locations
NCT05424783: Recruiting study of Prostate Cancer, sponsored by Northwestern University.
NCT05424783 is a study of Prostate Cancer that is actively recruiting participants, run by Northwestern University. The registered enrollment target is 222 participants, below the 608-participant average among 735 other Prostate Cancer trials with a reported enrollment target (63% lower). The trial reports 2 study locations across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05424783, a study of Prostate Cancer, is actively recruiting participants, sponsored by Northwestern University.
- RECRUITING
- Registry status
- 222 participants
- Enrollment target
- 2
- Study locations
Study Summary
The overarching goal is to prospectively recruit men considering active surveillance for treatment in the MAGIC (MRI And GPS Informing Choices for prostate cancer treatment) Cohort to provide meaningful data on active surveillance in Blacks and in men served in safety net hospitals. Recent studies highlight significant promise for multi-parametric magnetic resonance imaging of the prostate (MRI) and Genomic Prostate Score assay (GPS) as tools to help risk stratify men on active surveillance to identify men likely to harbor undetected aggressive disease in their prostate. Given the risk data provided by these modalities and the low adherence with monitoring common in men served in public hospitals, both tools may improve safety via improved patient selection and patient adherence with monitoring. The downside is that excessive testing may lead to too many false positives and unnecessary treatment. Two hundred men with very low to intermediate risk prostate cancer were randomized into the 2-arm ENACT Clinical trial from 2016-2019 to study the impact of the GPS assay on treatment choice. Overall, 104 men received GPS assay and 96 controls did not receive the assay (a confirmatory test) right after being newly diagnosed with favorable risk prostate cancer. For Aim 1, 222 men will be recruited into the MRI And GPS Informing Choices for prostate cancer treatment (MAGIC) study and they will be given the GPS assay and multi-parametric MRI of the prostate to provide personalized risk data for having aggressive tumors in their prostate. Between the ENACT and MAGIC study, there will be 3 groups of men who will have received both GPS \& MRI, GPS alone, or neither test and can compare the impact of having 0,1 or 2 confirmatory tests on patient's adherence to active surveillance monitoring protocols over 18 months. The analyses will elucidate whether 1 or 2 tests are needed to improve adherence to monitoring. Monitoring is vital for detecting tumor progression early and avoiding
Primary Outcome
The men in the MAGIC study who chose active surveillance that complete their active surveillance prostate biopsy by 18 months after their diagnostic prostate biopsy will be compared to men who chose active surveillance in the ENACT Clinical Trial who received GPS alone (ENACT intervention arm) or neither GPS nor prostate MRI (ENACT control arm).
Conditions Studied
Interventions
- OTHER Genomic Prostate Score assay and Multi-parametric magnetic resonance imaging study of the prostate
Study Locations (2)
Illinois
- Northwestern University - Chicago
- University of Illinois at Chicago - Chicago
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 222 participants |
| Start Date | 2022-10-15 |
| Est. Completion | 2025-12-31 |
What NCT05424783 shows while recruiting
NCT05424783 is an observational study that tracks outcomes without assigning an intervention. The registered 222 participants enrollment target is mid-sized for trials with a published cap, below the 608-participant average among 735 other Prostate Cancer trials with a reported enrollment target (63% lower).
The record links to 1 condition, with Prostate Cancer appearing as the primary indexed condition, and to 1 intervention - of which Genomic Prostate Score assay and Multi-parametric magnetic resonance imaging study of the prostate is the first listed.
NCT05424783 reports a single indexed study location in Illinois.
Frequently Asked Questions
What is clinical trial NCT05424783 about?
NCT05424783 is a clinical study titled "MRI And GPS Informing Choices for Prostate Cancer Treatment (MAGIC)". The overarching goal is to prospectively recruit men considering active surveillance for treatment in the MAGIC (MRI And GPS Informing Choices for prostate cancer treatment) Cohort to provide meaningful data on active surveillance in Blacks and in men served in safety net hospitals. Recent studies h...
What is the current status of trial NCT05424783?
This trial is currently recruiting. The enrollment target is 222 participants. The study started on 2022-10-15. Estimated completion is 2025-12-31.
What conditions does trial NCT05424783 study?
This clinical trial studies the following conditions: Prostate Cancer.
What interventions are being tested in trial NCT05424783?
The interventions under investigation include: Genomic Prostate Score assay and Multi-parametric magnetic resonance imaging study of the prostate (OTHER).
Who is sponsoring clinical trial NCT05424783?
This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05424783 being conducted?
This trial has 2 study locations across Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05424783's enrollment target sits among peer trials
222 206th of 735 higher than 529 of 735 other Prostate Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Prostate Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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