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NCT05412381 · ClinicalTrials.gov registry record · Phase 3
PRP in ACLR to Prevent PTOA
A Phase 3 study of Anterior Cruciate Ligament Injuries and Post-traumatic Osteoarthritis, sponsored by Hospital for Special Surgery, New York.
- Recruiting
- Registry status
- Phase 3
- Development phase
- 56
- Enrollment target
- 1
- Study location
NCT05412381: Recruiting Phase 3 study of Anterior Cruciate Ligament Injuries and Post-traumatic Osteoarthritis, sponsored by Hospital for Special Surgery, New York.
NCT05412381 is a Phase 3 study of Anterior Cruciate Ligament Injuries and Post-traumatic Osteoarthritis that is actively recruiting participants, run by Hospital for Special Surgery, New York. The registered enrollment target is 56 participants, below the 321-participant average among 24 other Anterior Cruciate Ligament Injuries trials with a reported enrollment target (83% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05412381, a Phase 3 study of Anterior Cruciate Ligament Injuries and Post-traumatic Osteoarthritis, is actively recruiting participants, sponsored by Hospital for Special Surgery, New York.
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 56 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of our study is to examine the effect of platelet-rich-plasma (PRP) injection on the short-term resolution of post-injury inflammation (biomarkers) and improvement in joint function in patients with acute ACL injury. This RCT has been powered based on the questionnaire KOOS Jr. but it is considered a 'pilot study' in terms of the lab analysis proposed.
Primary Outcome
Platelet count (Thousand/uL) will be measured by completing a complete blood count on patient's blood sample.
Conditions Studied
Interventions
- PROCEDURE platelet rich plasma (PRP) injection
- PROCEDURE placebo saline injection
Study Locations (1)
New York
- Hospital for Special Surgery - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 56 participants |
| Start Date | 2022-06-27 |
| Est. Completion | 2026-12-31 |
| Phase | Phase 3 |
What NCT05412381 shows while recruiting
NCT05412381 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 56 participants, a relatively small participant target, below the 321-participant average among 24 other Anterior Cruciate Ligament Injuries trials with a reported enrollment target (83% lower).
The record links to 3 conditions, with Anterior Cruciate Ligament Injuries appearing as the primary indexed condition, and to 2 interventions - of which platelet rich plasma (PRP) injection is the first listed.
NCT05412381 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT05412381 about?
NCT05412381 is a clinical study titled "PRP in ACLR to Prevent PTOA". The purpose of our study is to examine the effect of platelet-rich-plasma (PRP) injection on the short-term resolution of post-injury inflammation (biomarkers) and improvement in joint function in patients with acute ACL injury. This RCT has been powered based on the questionnaire KOOS Jr. but it is...
What is the current status of trial NCT05412381?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 56 participants. The study started on 2022-06-27. Estimated completion is 2026-12-31.
What conditions does trial NCT05412381 study?
This clinical trial studies the following conditions: Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis, PRP.
What interventions are being tested in trial NCT05412381?
The interventions under investigation include: platelet rich plasma (PRP) injection (PROCEDURE), placebo saline injection (PROCEDURE).
Who is sponsoring clinical trial NCT05412381?
This trial is sponsored by Hospital for Special Surgery, New York, which has 194 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05412381 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05412381's enrollment target sits among peer trials
56 18th of 24 higher than 6 of 24 other Anterior Cruciate Ligament Injuries trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Anterior Cruciate Ligament Injuries trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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