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ClinicalTrials.gov 16 recruiting now official registry

Anterior Cruciate Ligament Injuries clinical trials

Every US clinical trial registered for Anterior Cruciate Ligament Injuries — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

25 US clinical trials · 16 currently recruiting

The research picture

Anterior Cruciate Ligament Injuries has 25 registered US clinical trials, 16 of them open to new participants right now — about 64% of the total.

16
recruiting participants now
64%
of trials open to enrollment
5
in Phase 3–4 (later-stage)
3
top sponsor: Hospital for Special Surgery, New York

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 5,000 participants

Baseline ACL Injury Risk Screening and Normative Data

Sanford Health

NCT06635668

RECRUITING NA 114 participants

Vibration and Post-traumatic Osteoarthritis Risk Following ACL Injury

University of North Carolina, Chapel Hill

NCT04875052

RECRUITING NA 100 participants

Quadriceps Tendon Versus Bone Patellar Tendon Bone Autograft ACL Reconstruction RCT

University of Alabama at Birmingham

NCT05461326

RECRUITING NA 96 participants

Bracing and Reconstruction of the Anterior Cruciate Ligament for Efficacy Trial

Wake Forest University Health Sciences

NCT06942754

RECRUITING Phase 4 84 participants

Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction

The Methodist Hospital Research Institute

NCT06511232

RECRUITING Phase 4 78 participants

IPACK on Early Pain Scores After ACL Reconstruction

Loyola University

NCT05985629

RECRUITING NA 70 participants

Gait Rehabilitation to Treat FastOA

University of North Carolina, Chapel Hill

NCT05848622

RECRUITING NA 60 participants

Anterior Cruciate Ligament Recovery With Virtual Psychological Intervention

Henry Ford Health System

NCT05965310

RECRUITING NA 60 participants

Dynamic Muscular Electrical Stimulation Following Anterior Cruciate Ligament Reconstruction in Military Academy Cadets

Keller Army Community Hospital

NCT06341868

RECRUITING NA 60 participants

External Focus of Attention Feedback to Reduce Risk of Non-contact ACL Injury

University of North Carolina, Charlotte

NCT04914689

RECRUITING NA 56 participants

Steps Towards Osteoarthritis Prevention

University of Georgia

NCT06193343

RECRUITING Phase 3 56 participants

PRP in ACLR to Prevent PTOA

Hospital for Special Surgery, New York

NCT05412381

RECRUITING NA 50 participants

Graded Exposure and Mindfulness Meditation for Patients Post-ACL Reconstruction

University of North Carolina, Chapel Hill

NCT05949177

RECRUITING Phase 4 40 participants

Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction

Hospital for Special Surgery, New York

NCT06311513

RECRUITING NA 40 participants

The Impact of Blood Flow Restriction Training in Adolescents After ACL Reconstruction: A Randomized Controlled Trial

Connecticut Children's Medical Center

NCT05754632

RECRUITING Early Phase 1 32 participants

Biologic Therapy to Prevent Osteoarthritis After ACL Injury

University of California, Los Angeles

NCT03968913

ACTIVE NOT RECRUITING 300 participants

A Prospective Cohort Post Market Registry Evaluating Outcomes of Bridge-Enhanced ACL Restoration (BEAR®)

Miach Orthopaedics

NCT05398341

ACTIVE NOT RECRUITING 181 participants

Micro-Doppler Radar: A Gold Standard Comparison

Milton S. Hershey Medical Center

NCT05521126

ACTIVE NOT RECRUITING NA 150 participants

Tendon-Bone Versus All-Soft-Tissue for ACL Reconstruction: A Patient-Blinded Randomized Clinical Trial

University of Colorado, Denver

NCT04039971

ACTIVE NOT RECRUITING NA 105 participants

Comparing Perioperative Education Modalities for ACL Reconstruction on Patient Satisfaction, Self-Efficacy, and Surgical Outcomes

Mayo Clinic

NCT05273463

ACTIVE NOT RECRUITING NA 28 participants

Utilization of a 3D Printed Customized Knee Extender and At-Home Rehabilitation Program on Patient Outcomes Following ACL Surgery

Sanford Health

NCT06524349

COMPLETED NA 671 participants

Knowledge Translation Intervention for ACL Injury Prevention Program in Youth Soccer

University of Michigan

NCT05442879

COMPLETED Phase 4 192 participants

Genicular Nerve Blocks for Anterior Cruciate Ligament Knee Surgery

Hospital for Special Surgery, New York

NCT05720949

COMPLETED NA 120 participants

Safe Options for ACL Recovery

Karen Derefinko, PhD

NCT04225468

COMPLETED NA 10 participants

Neuromuscular Control in Individuals Following ACL-Reconstruction

University of Virginia

NCT04495075

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 3 1
Phase 4 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Anterior Cruciate Ligament Injuries Trial Landscape

ClinicalTrials.gov lists 25 US studies indexed under Anterior Cruciate Ligament Injuries, and 16 of those are currently open to recruitment — roughly 64% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Anterior Cruciate Ligament Injuries shows 5 late-stage studies (Phase 3 and Phase 4 combined) alongside 1 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Anterior Cruciate Ligament Injuries is led by Hospital for Special Surgery, New York with 3 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 25 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Anterior Cruciate Ligament Injuries?

PlainTrial tracks 25 US clinical trials for Anterior Cruciate Ligament Injuries, of which 16 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Anterior Cruciate Ligament Injuries?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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