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Anterior Cruciate Ligament Injuries: later-stage trial registry
16 of 25 indexed Anterior Cruciate Ligament Injuries trials are currently recruiting, with more weight in Phase 3-4.
Corpus placement: #652 of 28,707 conditions by registered trial count.
25 US clinical trials · 16 currently recruiting · #652 of 28,707 conditions by registered trial count
Anterior Cruciate Ligament Injuries: 25 US clinical trials tracked, 16 recruiting.
Anterior Cruciate Ligament Injuries is the subject of 25 registered US clinical trials on ClinicalTrials.gov, 16 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 1 in Phase 1-2 (earlier-stage). The most active sponsor is Hospital for Special Surgery, New York, running 3 of these trials.
Enrollment posture brief
Registry condition anterior-cruciate-ligament-injuries
OPEN 16 | RECR 64% | LATE 5 | EARLY 1 | RANK #652 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Dysphagia (64% recruiting · 36 trials)
Anterior Cruciate Ligament Injuries lists 16 open slots (64% of 25 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Anterior Cruciate Ligament Injuries on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Anterior Cruciate Ligament Injuries is recruiting above its size-band peers.
16 of 25 indexed trials (64%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Anterior Cruciate Ligament Injuries trials is spread across many organizations.
Hospital for Special Surgery, New York accounts for 3 of 25 trials (12%). 20 distinct sponsors appear on at least one study for this condition label.
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Most Anterior Cruciate Ligament Injuries trials plan to enrol fewer than 100 people.
Median target enrolment is 78 among the 25 trials that report a genuine target (sentinel values excluded). 15 of those (60%) plan for fewer than 100 participants.
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Anterior Cruciate Ligament Injuries research is mostly interventional.
22 interventional and 3 observational studies make up this index (88% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
25 total, page 1 of 1
Baseline ACL Injury Risk Screening and Normative Data
Sanford Health
NCT06635668
Vibration and Post-traumatic Osteoarthritis Risk Following ACL Injury
University of North Carolina, Chapel Hill
NCT04875052
Quadriceps Tendon Versus Bone Patellar Tendon Bone Autograft ACL Reconstruction RCT
University of Alabama at Birmingham
NCT05461326
Bracing and Reconstruction of the Anterior Cruciate Ligament for Efficacy Trial
Wake Forest University Health Sciences
NCT06942754
Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction
The Methodist Hospital Research Institute
NCT06511232
IPACK on Early Pain Scores After ACL Reconstruction
Loyola University
NCT05985629
Gait Rehabilitation to Treat FastOA
University of North Carolina, Chapel Hill
NCT05848622
Anterior Cruciate Ligament Recovery With Virtual Psychological Intervention
Henry Ford Health System
NCT05965310
Dynamic Muscular Electrical Stimulation Following Anterior Cruciate Ligament Reconstruction in Military Academy Cadets
Keller Army Community Hospital
NCT06341868
External Focus of Attention Feedback to Reduce Risk of Non-contact ACL Injury
University of North Carolina, Charlotte
NCT04914689
Steps Towards Osteoarthritis Prevention
University of Georgia
NCT06193343
PRP in ACLR to Prevent PTOA
Hospital for Special Surgery, New York
NCT05412381
Graded Exposure and Mindfulness Meditation for Patients Post-ACL Reconstruction
University of North Carolina, Chapel Hill
NCT05949177
Concentrated Bone Marrow Aspirate in Revision ACL Reconstruction
Hospital for Special Surgery, New York
NCT06311513
The Impact of Blood Flow Restriction Training in Adolescents After ACL Reconstruction: A Randomized Controlled Trial
Connecticut Children's Medical Center
NCT05754632
Biologic Therapy to Prevent Osteoarthritis After ACL Injury
University of California, Los Angeles
NCT03968913
A Prospective Cohort Post Market Registry Evaluating Outcomes of Bridge-Enhanced ACL Restoration (BEAR®)
Miach Orthopaedics
NCT05398341
Micro-Doppler Radar: A Gold Standard Comparison
Milton S. Hershey Medical Center
NCT05521126
Tendon-Bone Versus All-Soft-Tissue for ACL Reconstruction: A Patient-Blinded Randomized Clinical Trial
University of Colorado, Denver
NCT04039971
Comparing Perioperative Education Modalities for ACL Reconstruction on Patient Satisfaction, Self-Efficacy, and Surgical Outcomes
Mayo Clinic
NCT05273463
Utilization of a 3D Printed Customized Knee Extender and At-Home Rehabilitation Program on Patient Outcomes Following ACL Surgery
Sanford Health
NCT06524349
Knowledge Translation Intervention for ACL Injury Prevention Program in Youth Soccer
University of Michigan
NCT05442879
Genicular Nerve Blocks for Anterior Cruciate Ligament Knee Surgery
Hospital for Special Surgery, New York
NCT05720949
Safe Options for ACL Recovery
Karen Derefinko, PhD
NCT04225468
Neuromuscular Control in Individuals Following ACL-Reconstruction
University of Virginia
NCT04495075
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 3 | 1 |
| Phase 4 | 4 |
Top Sponsors
Named interventions
Most-linked intervention names on Anterior Cruciate Ligament Injuries records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Anterior Cruciate Ligament Injuries trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Anterior Cruciate Ligament Injuries page
25 registered trials, 16 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 16 Anterior Cruciate Ligament Injuries trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Hospital for Special Surgery, New York sponsors the most Anterior Cruciate Ligament Injuries trials on record, review their full trial history before evaluating a specific study. See Hospital for Special Surgery, New York's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Anterior Cruciate Ligament Injuries condition card totals 25 registered trials; most-linked intervention ACL Opioid Exposure Reduction Program; top US site state North Carolina. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.