Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05351333 · ClinicalTrials.gov registry record · NA
Conditioning & Open-Label Placebo (COLP) for Opioid Management in Intensive Inpatient Rehabilitation
A NA study of Spinal Cord Injuries and Burns, sponsored by Spaulding Rehabilitation Hospital.
- Active
- Registry status
- NA
- Development phase
- 66
- Enrollment target
- 1
- Study location
NCT05351333: Active NA study of Spinal Cord Injuries and Burns, sponsored by Spaulding Rehabilitation Hospital.
NCT05351333 is a NA study of Spinal Cord Injuries and Burns that is active but no longer recruiting, run by Spaulding Rehabilitation Hospital. The registered enrollment target is 66 participants, roughly in line with the 61-participant average among 202 other Spinal Cord Injuries trials with a reported enrollment target. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05351333, a NA study of Spinal Cord Injuries and Burns, is active but no longer recruiting, sponsored by Spaulding Rehabilitation Hospital.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 66 participants
- Enrollment target
- 1
- Study location
Study Summary
The use of the conditioning open-label placebo (COLP) paradigm will be studied as a dose extension method to lower opioid dosage in patients with spinal cord injury, polytrauma, and burn injury. The goal is to provide the same level of pain relief with a reduced opioid intake to diminish side effects as well as the risk of addiction associated with opioid treatment.
Primary Outcome
The opioid morphine equivalent conversion factor is used to standardized opioid usage having as a reference morphine as main indicator for analgesic potency.
Conditions Studied
Interventions
- OTHER placebo
Study Locations (1)
Massachusetts
- Spaulding Rehabilitation Hospital - Charlestown
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 66 participants |
| Start Date | 2022-08-03 |
| Est. Completion | 2026-07-31 |
| Phase | NA |
What the registry record for NCT05351333 still lists
NCT05351333 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 66 participants, a relatively small participant target, roughly in line with the 61-participant average among 202 other Spinal Cord Injuries trials with a reported enrollment target.
The record links to 3 conditions, with Spinal Cord Injuries appearing as the primary indexed condition, and to 1 intervention - of which placebo is the first listed.
NCT05351333 reports a single indexed study location in Massachusetts.
Frequently Asked Questions
What is clinical trial NCT05351333 about?
NCT05351333 is a clinical study titled "Conditioning & Open-Label Placebo (COLP) for Opioid Management in Intensive Inpatient Rehabilitation". The use of the conditioning open-label placebo (COLP) paradigm will be studied as a dose extension method to lower opioid dosage in patients with spinal cord injury, polytrauma, and burn injury. The goal is to provide the same level of pain relief with a reduced opioid intake to diminish side effect...
What is the current status of trial NCT05351333?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 66 participants. The study started on 2022-08-03. Estimated completion is 2026-07-31.
What conditions does trial NCT05351333 study?
This clinical trial studies the following conditions: Spinal Cord Injuries, Burns, Polytrauma.
What interventions are being tested in trial NCT05351333?
The interventions under investigation include: placebo (OTHER).
Who is sponsoring clinical trial NCT05351333?
This trial is sponsored by Spaulding Rehabilitation Hospital, which has 101 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05351333 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Spinal Cord Injuries
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05351333's enrollment target sits among peer trials
66 46th of 202 higher than 157 of 202 other Spinal Cord Injuries trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Spinal Cord Injuries trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-02)
RECRUITING · NA
-
Closed-loop Spinal Stimulation for Restoration of Upper Extremity Function After Spinal Cord Injury
RECRUITING · NA
-
Neuromodulation to Improve Respiratory Function in Cervical Spinal Cord Injury
RECRUITING · NA
-
Transcutaneous Spinal Stimulation and Exercise for Locomotion
RECRUITING · NA
-
HAPPINESS: cHAnging the Perceived Pain INtEnSity in Populations With Spinal Cord Injury and With Health Disparities: A Feasibility Study
RECRUITING · NA
-
Dosing rTMS for Depression Post-SCI
RECRUITING · NA
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02584244 · 66 participants · Phase 1
Feasibility of the LUM Imaging System for Detection of Gastrointestinal Cancers
- NCT03067051 · 66 participants · Phase 1
Clinical Study to Assess the Safety and Efficacy of the SpectraCure P18 System
- NCT03754725 · 66 participants · Phase 1
Ferritin and Iron Burden in SAH sIRB
- NCT03875378 · 66 participants · Phase 2
Transdermal Estrogen in Women With Anorexia Nervosa
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT06358040 · started 2026-10 · NA
Opioid Dispenser for Microdiscectomy/Laminectomy