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NCT05329441 · ClinicalTrials.gov registry record
Inflammatory and Glutamatergic Mechanisms of Sustained Threat in Adolescents With Depression
A clinical trial of Depression in Adolescence, sponsored by University of California, Los Angeles.
- Recruiting
- Registry status
- 160
- Enrollment target
- 1
- Study location
NCT05329441: Recruiting study of Depression in Adolescence, sponsored by University of California, Los Angeles.
NCT05329441 is a study of Depression in Adolescence that is actively recruiting participants, run by University of California, Los Angeles. The registered enrollment target is 160 participants, roughly in line with the 150-participant average among 7 other Depression in Adolescence trials with a reported enrollment target. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05329441, a study of Depression in Adolescence, is actively recruiting participants, sponsored by University of California, Los Angeles.
- RECRUITING
- Registry status
- 160 participants
- Enrollment target
- 1
- Study location
Study Summary
Despite the prevalence and significant public health concern over depression among adolescents, up to 40% of depressed adolescents do not respond to first-line antidepressants (herein termed treatment non-response, TNR). The goal of this project is to recruit and assess 160 treatment-seeking depressed adolescents and test whether acute stress impacts peripheral levels of inflammation and downstream levels of glutamate in corticolimbic regions previously associated with depression, whether these stress-related biomarkers predict TNR to a 12-week trial of either fluoxetine or escitalopram, and whether these stress-related biomarkers predict 18-month clinical course.
Primary Outcome
Clinician-administered assessment of depression severity (dimensional) assessment of depression Clinician-administered assessment of depression severity (dimensional)
Conditions Studied
Interventions
- BEHAVIORAL Trier Social Stress Test (TSST)
Study Locations (1)
California
- University of California, Los Angeles - Los Angeles
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 160 participants |
| Start Date | 2023-07-06 |
| Est. Completion | 2028-04-30 |
What NCT05329441 shows while recruiting
NCT05329441 is an observational study that tracks outcomes without assigning an intervention. The registered 160 participants enrollment target is mid-sized for trials with a published cap, roughly in line with the 150-participant average among 7 other Depression in Adolescence trials with a reported enrollment target.
The record links to 1 condition, with Depression in Adolescence appearing as the primary indexed condition, and to 1 intervention - of which Trier Social Stress Test (TSST) is the first listed.
NCT05329441 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT05329441 about?
NCT05329441 is a clinical study titled "Inflammatory and Glutamatergic Mechanisms of Sustained Threat in Adolescents With Depression". Despite the prevalence and significant public health concern over depression among adolescents, up to 40% of depressed adolescents do not respond to first-line antidepressants (herein termed treatment non-response, TNR). The goal of this project is to recruit and assess 160 treatment-seeking depress...
What is the current status of trial NCT05329441?
This trial is currently recruiting. The enrollment target is 160 participants. The study started on 2023-07-06. Estimated completion is 2028-04-30.
What conditions does trial NCT05329441 study?
This clinical trial studies the following conditions: Depression in Adolescence.
What interventions are being tested in trial NCT05329441?
The interventions under investigation include: Trier Social Stress Test (TSST) (BEHAVIORAL).
Who is sponsoring clinical trial NCT05329441?
This trial is sponsored by University of California, Los Angeles, which has 897 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05329441 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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