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NCT05255276 · ClinicalTrials.gov registry record · Phase 1
PK Study to Assess Drug-drug Interaction Between Sitravatinib and a P-gp Inducer and an Inhibitor.
A Phase 1 study, sponsored by Mirati Therapeutics.
- Completed
- Registry status
- Phase 1
- Development phase
- 36
- Enrollment target
NCT05255276: Completed Phase 1 study, sponsored by Mirati Therapeutics.
NCT05255276 is a Phase 1 study that has completed, run by Mirati Therapeutics. The registered enrollment target is 36 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (40% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05255276, a Phase 1 study, has completed, sponsored by Mirati Therapeutics.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 36 participants
- Enrollment target
Study Summary
A Phase 1 Open-label, Two-cohort, One-sequence Crossover Study to Investigate the Effect of P glycoprotein Inhibitor (Itraconazole) and Inducer (Rifampin) on the Pharmacokinetics, Safety, and Tolerability of Sitravatinib in Healthy Subjects.
Primary Outcome
Maximum observed plasma concentration
Interventions
- DRUG Rifampin
- DRUG Itraconazole
- DRUG Sitravatinib 50 mg
- DRUG Sitravatinib 100 mg
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 36 participants |
| Start Date | 2022-02-02 |
| Est. Completion | 2023-02-10 |
| Phase | Phase 1 |
What the finished NCT05255276 record still lists
NCT05255276 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 36 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (40% lower).
The record links to 0 conditions, and to 4 interventions - of which Rifampin is the first listed.
NCT05255276 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05255276 about?
NCT05255276 is a clinical study titled "PK Study to Assess Drug-drug Interaction Between Sitravatinib and a P-gp Inducer and an Inhibitor.". A Phase 1 Open-label, Two-cohort, One-sequence Crossover Study to Investigate the Effect of P glycoprotein Inhibitor (Itraconazole) and Inducer (Rifampin) on the Pharmacokinetics, Safety, and Tolerability of Sitravatinib in Healthy Subjects.
What is the current status of trial NCT05255276?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 36 participants. The study started on 2022-02-02. Estimated completion is 2023-02-10.
What interventions are being tested in trial NCT05255276?
The interventions under investigation include: Rifampin (DRUG), Itraconazole (DRUG), Sitravatinib 50 mg (DRUG), Sitravatinib 100 mg (DRUG).
Who is sponsoring clinical trial NCT05255276?
This trial is sponsored by Mirati Therapeutics, which has 49 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05255276's enrollment target sits among peer trials
36 1210th of 2000 higher than 743 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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