Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Study of Selinexor Plus DRd for Newly Diagnosed Multiple Myeloma
NCT04782687 · View on ClinicalTrials.gov ↗
Study Summary
This is a single-arm, phase II, open-label trial to investigate the effects of selinexor (S) in combination with daratumumab, lenalidomide, and dexamethasone (DRd) for first-line treatment of multiple myeloma (MM). FDA has approved selinexor plus dexamethasone in multiple myeloma after four prior therapies, and DRd is also already approved by the FDA for multiple myeloma. This study will use all four (S-DRd) together to treat MM as an initial treatment.
Conditions Studied
Interventions
- DRUG Selinexor
- DRUG Lenalidomide
- DRUG Daratumumab
- DRUG Dexamethasone Oral
Study Locations (10)
Texas
- Texas Oncology, P.A. — Austin
- Texas Oncology, P.A. — Fort Worth
- Texas Oncology, P.A. — San Antonio
- Texas Oncology, P.A. — Tyler
Arizona
- Arizona Oncology Associates, PC - HOPE — Tucson
Colorado
- Rocky Mountain Cancer Centers — Denver
Maryland
- Maryland Oncology Hematology, P.A. — Columbia
New York
- New York Oncology Hematology, P.C. — Albany
Oregon
- Willamette Valley Cancer Institute and Research Center — Eugene
Virginia
- Virginia Cancer Specialists, PC — Gainesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 73 participants |
| Start Date | 2021-09-10 |
| Est. Completion | 2026-05-31 |
| Phase | Phase 2 |
Interested in This Trial?
Always speak with your doctor before enrolling in a clinical trial.
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04782687
The ClinicalTrials.gov registry entry for NCT04782687 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 73 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is US Oncology Research, which has 9 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 7 conditions, with Multiple Myeloma appearing as the primary indexed condition, and to 4 interventions — of which Selinexor is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04782687 reports 10 study locations spanning 7 distinct geographic areas — top geographies include Texas, Arizona, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04782687 about?
NCT04782687 is a clinical study titled "Study of Selinexor Plus DRd for Newly Diagnosed Multiple Myeloma". This is a single-arm, phase II, open-label trial to investigate the effects of selinexor (S) in combination with daratumumab, lenalidomide, and dexamethasone (DRd) for first-line treatment of multiple myeloma (MM). FDA has approved selinexor plus dexamethasone in multiple myeloma after four prior t...
What is the current status of trial NCT04782687?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 73 participants. The study started on 2021-09-10. Estimated completion is 2026-05-31.
What conditions does trial NCT04782687 study?
This clinical trial studies the following conditions: Multiple Myeloma, Plasma Cell Myeloma, Myeloma Multiple, Myeloma-Multiple, Kahler Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04782687?
The interventions under investigation include: Selinexor (DRUG), Lenalidomide (DRUG), Daratumumab (DRUG), Dexamethasone Oral (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04782687?
This trial is sponsored by US Oncology Research, which has 9 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04782687 being conducted?
This trial has 10 study locations across Arizona, Colorado, Maryland, New York, Oregon. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How Clinical Trials Work
Understand phases 1-4, trial design, randomization, and the informed consent process.
Patient Rights in Clinical Trials
Your rights as a participant: consent, withdrawal, privacy, and who to contact.
Finding the Right Clinical Trial
A practical guide to searching trials, understanding eligibility, and evaluating options.
All Guides
Browse our complete library of clinical trial educational resources.
Read our methodology — how this data is sourced, computed, and verified.