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NCT05108818 · ClinicalTrials.gov registry record · Phase 4
Characterization of Humoral and Cellular Immune Responses Elicited by Influenza Vaccination in Healthy Adults
A Phase 4 study of Influenza, Human, sponsored by University of Pennsylvania.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 700
- Enrollment target
- 1
- Study location
NCT05108818: Recruiting Phase 4 study of Influenza, Human, sponsored by University of Pennsylvania.
NCT05108818 is a Phase 4 study of Influenza, Human that is actively recruiting participants, run by University of Pennsylvania. The registered enrollment target is 700 participants, below the 16,185-participant average among 18 other Influenza, Human trials with a reported enrollment target (96% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05108818, a Phase 4 study of Influenza, Human, is actively recruiting participants, sponsored by University of Pennsylvania.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 700 participants
- Enrollment target
- 1
- Study location
Study Summary
Cellular and humoral immune responses before and after seasonal influenza vaccination will be assessed. Each year, up to 100 participants will be enrolled. To study age-specific differences in immune responses, participants with various years of birth will be enrolled. The investigators hypothesize that humans with different birth years will mount antibody and cellular responses of different specificities following seasonal influenza vaccination.
Primary Outcome
Because year of birth can be used to predict the influenza viruses circulating during the first years of life, assessing antibody responses in individuals of different birth years is one way of determining how prior exposure affects immune responses to seasonal influenza vaccination and infection. The investigators will assess how antibody responses to seasonal influenza vaccination differ in individuals across multiple age groups. Baseline serum neutralizing antibodies to post-vaccination serum
Conditions Studied
Interventions
- BIOLOGICAL Seasonal influenza vaccine
Study Locations (1)
Pennsylvania
- University of Pennsylvania - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 700 participants |
| Start Date | 2021-10-07 |
| Est. Completion | 2028-03-31 |
| Phase | Phase 4 |
What NCT05108818 shows while recruiting
NCT05108818 is an interventional study that assigns participants to a tested intervention. The registered 700 participants enrollment target is mid-sized for trials with a published cap, below the 16,185-participant average among 18 other Influenza, Human trials with a reported enrollment target (96% lower).
The record links to 1 condition, with Influenza, Human appearing as the primary indexed condition, and to 1 intervention - of which Seasonal influenza vaccine is the first listed.
NCT05108818 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT05108818 about?
NCT05108818 is a clinical study titled "Characterization of Humoral and Cellular Immune Responses Elicited by Influenza Vaccination in Healthy Adults". Cellular and humoral immune responses before and after seasonal influenza vaccination will be assessed. Each year, up to 100 participants will be enrolled. To study age-specific differences in immune responses, participants with various years of birth will be enrolled. The investigators hypothesize ...
What is the current status of trial NCT05108818?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 700 participants. The study started on 2021-10-07. Estimated completion is 2028-03-31.
What conditions does trial NCT05108818 study?
This clinical trial studies the following conditions: Influenza, Human.
What interventions are being tested in trial NCT05108818?
The interventions under investigation include: Seasonal influenza vaccine (BIOLOGICAL).
Who is sponsoring clinical trial NCT05108818?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05108818 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Influenza, Human
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05108818's enrollment target sits among peer trials
700 9th of 18 higher than 10 of 18 other Influenza, Human trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Influenza, Human trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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