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NCT05077735 · ClinicalTrials.gov registry record · Phase 2
Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Study
A Phase 2 study of Diffuse Midline Glioma, H3 K27M-Mutant, sponsored by Mayo Clinic.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 29
- Enrollment target
- 2
- Study locations
NCT05077735: Recruiting Phase 2 study of Diffuse Midline Glioma, H3 K27M-Mutant, sponsored by Mayo Clinic.
NCT05077735 is a Phase 2 study of Diffuse Midline Glioma, H3 K27M-Mutant that is actively recruiting participants, run by Mayo Clinic. The registered enrollment target is 29 participants, below the 231-participant average among 11 other Diffuse Midline Glioma, H3 K27M-Mutant trials with a reported enrollment target (87% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05077735, a Phase 2 study of Diffuse Midline Glioma, H3 K27M-Mutant, is actively recruiting participants, sponsored by Mayo Clinic.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 29 participants
- Enrollment target
- 2
- Study locations
Study Summary
This phase II trial studies the clinical outcomes of hypofractionated radiation therapy in patients with diffuse midline gliomas. This study aims to change the way radiation is delivered, from giving 6 weeks of radiation all at once to giving 2 weeks of radiation. This may determine if there is a difference in the outcome of the treatment, and most importantly, the patients' quality of life.
Primary Outcome
Defined as the time from date of diagnosis to the date of radiographic or clinical progression following second course of hypofractionated radiation therapy.
Conditions Studied
Interventions
- PROCEDURE Magnetic Resonance Imaging
- OTHER Questionnaire Administration
- RADIATION Hypofractionated Radiation Therapy
- PROCEDURE Positron Emission Tomography and Computed Tomography Scan
Study Locations (2)
Arizona
- Mayo Clinic Hospital in Arizona - Phoenix
Minnesota
- Mayo Clinic in Rochester - Rochester
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 29 participants |
| Start Date | 2021-10-11 |
| Est. Completion | 2027-10-15 |
| Phase | Phase 2 |
What NCT05077735 shows while recruiting
NCT05077735 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 29 participants, a relatively small participant target, below the 231-participant average among 11 other Diffuse Midline Glioma, H3 K27M-Mutant trials with a reported enrollment target (87% lower).
The record links to 1 condition, with Diffuse Midline Glioma, H3 K27M-Mutant appearing as the primary indexed condition, and to 4 interventions - of which Magnetic Resonance Imaging is the first listed.
NCT05077735 reports a single indexed study location in Arizona, Minnesota.
Frequently Asked Questions
What is clinical trial NCT05077735 about?
NCT05077735 is a clinical study titled "Stereotactic Biopsy Split-Course Radiation Therapy in Diffuse Midline Glioma, SPORT-DMG Study". This phase II trial studies the clinical outcomes of hypofractionated radiation therapy in patients with diffuse midline gliomas. This study aims to change the way radiation is delivered, from giving 6 weeks of radiation all at once to giving 2 weeks of radiation. This may determine if there is a di...
What is the current status of trial NCT05077735?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 29 participants. The study started on 2021-10-11. Estimated completion is 2027-10-15.
What conditions does trial NCT05077735 study?
This clinical trial studies the following conditions: Diffuse Midline Glioma, H3 K27M-Mutant.
What interventions are being tested in trial NCT05077735?
The interventions under investigation include: Magnetic Resonance Imaging (PROCEDURE), Questionnaire Administration (OTHER), Hypofractionated Radiation Therapy (RADIATION), Positron Emission Tomography and Computed Tomography Scan (PROCEDURE).
Who is sponsoring clinical trial NCT05077735?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05077735 being conducted?
This trial has 2 study locations across Arizona, Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05077735's enrollment target sits among peer trials
29 8th of 11 higher than 4 of 11 other Diffuse Midline Glioma, H3 K27M-Mutant trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Diffuse Midline Glioma, H3 K27M-Mutant trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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