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NCT05018091 · ClinicalTrials.gov registry record · Phase 4
Dexamethasone in Total Knee Arthroplasty
A Phase 4 study, sponsored by Rush University Medical Center.
- Completed
- Registry status
- Phase 4
- Development phase
- 404
- Enrollment target
NCT05018091: Completed Phase 4 study, sponsored by Rush University Medical Center.
NCT05018091 is a Phase 4 study that has completed, run by Rush University Medical Center. The registered enrollment target is 404 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (22% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05018091, a Phase 4 study, has completed, sponsored by Rush University Medical Center.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 404 participants
- Enrollment target
Study Summary
The purpose of this study is to determine the most efficacious and safest dexamethasone dose given intraoperatively during total knee arthroplasty that reduces postoperative opioid consumption and pain, improves postoperative nausea and vomiting, and minimizes postoperative complications.
Primary Outcome
48 hours of cumulative opioid consumption measured in oral morphine equivalents
Interventions
- DRUG Dexamethasone 4mg
- DRUG Dexamethasone 8 Mg/mL Injectable Suspension
- DRUG Dexamethasone 16mg
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 404 participants |
| Start Date | 2021-10-28 |
| Est. Completion | 2025-05-30 |
| Phase | Phase 4 |
What the finished NCT05018091 record still lists
NCT05018091 is an interventional study that assigns participants to a tested intervention. The registered 404 participants enrollment target is mid-sized for trials with a published cap, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (22% lower).
The record links to 0 conditions, and to 3 interventions - of which Dexamethasone 4mg is the first listed.
NCT05018091 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05018091 about?
NCT05018091 is a clinical study titled "Dexamethasone in Total Knee Arthroplasty". The purpose of this study is to determine the most efficacious and safest dexamethasone dose given intraoperatively during total knee arthroplasty that reduces postoperative opioid consumption and pain, improves postoperative nausea and vomiting, and minimizes postoperative complications.
What is the current status of trial NCT05018091?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 404 participants. The study started on 2021-10-28. Estimated completion is 2025-05-30.
What interventions are being tested in trial NCT05018091?
The interventions under investigation include: Dexamethasone 4mg (DRUG), Dexamethasone 8 Mg/mL Injectable Suspension (DRUG), Dexamethasone 16mg (DRUG).
Who is sponsoring clinical trial NCT05018091?
This trial is sponsored by Rush University Medical Center, which has 320 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05018091's enrollment target sits among peer trials
404 209th of 2000 higher than 1,791 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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