Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04974385 · ClinicalTrials.gov registry record · Phase 3
Liposomal Bupivacaine Versus Non-liposomal Bupivacaine for Total Shoulder Arthroplasty
A Phase 3 study of Analgesia, sponsored by University of Virginia.
- Completed
- Registry status
- Phase 3
- Development phase
- 80
- Enrollment target
- 1
- Study location
NCT04974385: Completed Phase 3 study of Analgesia, sponsored by University of Virginia.
NCT04974385 is a Phase 3 study of Analgesia that has completed, run by University of Virginia. The registered enrollment target is 80 participants, below the 89-participant average among 19 other Analgesia trials with a reported enrollment target (10% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04974385, a Phase 3 study of Analgesia, has completed, sponsored by University of Virginia.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 80 participants
- Enrollment target
- 1
- Study location
Study Summary
The objective of this study is to validate the analgesic efficacy of admixed Liposomal bupivacaine (LB) + bupivacaine compared with plain bupivacaine when injected for interscalene nerve block (ISNB) for total shoulder arthroplasty (TSA). We hypothesize that admixed LB will be non-inferior to plain bupivacaine in terms of postoperative opioid consumption following TSA. The primary outcome of this study will be opioid consumption over the first 72 hours following surgery. Secondary outcomes will include: pain scores, opioid-related adverse events, block related adverse events, pain related phone calls, pain related ED visits and patient satisfaction.
Primary Outcome
Morphine equivalents used during first 72 hours after surgery
Conditions Studied
Interventions
- DRUG Bupivacaine
- DRUG Liposomal bupivacaine
Study Locations (1)
Virginia
- University of Virginia Medical Center - Charlottesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2021-08-04 |
| Est. Completion | 2022-05-04 |
| Phase | Phase 3 |
What the finished NCT04974385 record still lists
NCT04974385 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 89-participant average among 19 other Analgesia trials with a reported enrollment target (10% lower).
The record links to 1 condition, with Analgesia appearing as the primary indexed condition, and to 2 interventions - of which Bupivacaine is the first listed.
NCT04974385 reports a single indexed study location in Virginia.
Frequently Asked Questions
What is clinical trial NCT04974385 about?
NCT04974385 is a clinical study titled "Liposomal Bupivacaine Versus Non-liposomal Bupivacaine for Total Shoulder Arthroplasty". The objective of this study is to validate the analgesic efficacy of admixed Liposomal bupivacaine (LB) + bupivacaine compared with plain bupivacaine when injected for interscalene nerve block (ISNB) for total shoulder arthroplasty (TSA). We hypothesize that admixed LB will be non-inferior to plain ...
What is the current status of trial NCT04974385?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 80 participants. The study started on 2021-08-04. Estimated completion is 2022-05-04.
What conditions does trial NCT04974385 study?
This clinical trial studies the following conditions: Analgesia.
What interventions are being tested in trial NCT04974385?
The interventions under investigation include: Bupivacaine (DRUG), Liposomal bupivacaine (DRUG).
Who is sponsoring clinical trial NCT04974385?
This trial is sponsored by University of Virginia, which has 449 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04974385 being conducted?
This trial has 1 study location across Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Analgesia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04974385's enrollment target sits among peer trials
80 12th of 19 higher than 7 of 19 other Analgesia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Analgesia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Thoracic Epidural Analgesia vs Surgical Site Infiltration With Liposomal Bupivacaine Following Open Gynecologic Surgery
COMPLETED · Phase 3
-
TENS Unit for Analgesia During IUD Insertion
RECRUITING · NA
-
Adductor Canal Block and IPACK Block vs. Isolated Adductor Canal Block for Post-Operative Analgesia Following HTO/DFO/TTO
RECRUITING · Phase 4
-
Transversus Abdominis Plane Block Compared to Local Anesthetic Wound Infiltration in Gynecologic Oncology Surgery
RECRUITING · Phase 4
-
Impact of the NeuroCuple Device on Pain Management After Cesarean Delivery
RECRUITING · NA
-
Evaluation of Pain Management After Surgery When Using Exparel in the Pediatric Population
RECRUITING · Phase 2
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01243931 · 80 participants · NA
Optical Coherence Tomography Guided Transepithelial Phototherapeutic Keratectomy
- NCT01659203 · 80 participants · Phase 1
Proton or Photon RT for Retroperitoneal Sarcomas
- NCT01803451 · 80 participants · Early Phase 1
Glucagon-like Peptide 1, Glucose Metabolism and Gastric Bypass
- NCT01964859 · 80 participants · Phase 2
Feasibility Study for Fibroblast Autologous Skin Grafts
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI