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NCT04973683 · ClinicalTrials.gov registry record · Phase 1

AL101 Before Surgery for the Treatment of Notch Activated Adenoid Cystic Cancer

A Phase 1 study of Adenoid Cystic Carcinoma and Metastatic Adenoid Cystic Carcinoma, sponsored by M.D. Anderson Cancer Center.

Active
Registry status
Phase 1
Development phase
14
Enrollment target
1
Study location

NCT04973683 is a Phase 1 study of Adenoid Cystic Carcinoma and Metastatic Adenoid Cystic Carcinoma that is active but no longer recruiting, run by M.D. Anderson Cancer Center. The registered enrollment target is 14 participants, below the 127-participant average among 16 other Adenoid Cystic Carcinoma trials with a reported enrollment target (89% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT04973683, a Phase 1 study of Adenoid Cystic Carcinoma and Metastatic Adenoid Cystic Carcinoma, is active but no longer recruiting, sponsored by M.D. Anderson Cancer Center.

ACTIVE NOT RECRUITING
Registry status
Phase 1
Development phase
14 participants
Enrollment target
1
Study location

Study Summary

This phase Ib trial studies the side effects and possible benefits of AL101 before surgery in treating patients with notch activated adenoid cystic cancer. AL101 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving AL101 before surgery may help to control adenoid cystic cancer that has a NOTCH pathway activation.

Conditions Studied

Adenoid Cystic Carcinoma Metastatic Adenoid Cystic Carcinoma

Interventions

  • PROCEDURE Therapeutic Conventional Surgery
  • DRUG AL101

Study Locations (1)

Texas

  • M D Anderson Cancer Center - Houston

Trial Details

FieldValue
Enrollment Target 14 participants
Start Date 2021-09-30
Est. Completion 2025-12-15
Phase Phase 1

Sponsor

M.D. Anderson Cancer Center

2,692 total trials

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What the Registry Record Tells You About NCT04973683

The ClinicalTrials.gov registry entry for NCT04973683 describes a study currently listed as active not recruiting, categorized as Phase 1. The registered enrollment target is 14 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 127-participant average among 16 other Adenoid Cystic Carcinoma trials with a reported enrollment target (89% lower). The listed sponsor is M.D. Anderson Cancer Center, which has 2,692 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Adenoid Cystic Carcinoma appearing as the primary indexed condition, and to 2 interventions - of which Therapeutic Conventional Surgery is the first listed.

NCT04973683 reports 1 study location spanning 1 distinct geographic area - top geographies include Texas.

Frequently Asked Questions

What is clinical trial NCT04973683 about?

NCT04973683 is a clinical study titled "AL101 Before Surgery for the Treatment of Notch Activated Adenoid Cystic Cancer". This phase Ib trial studies the side effects and possible benefits of AL101 before surgery in treating patients with notch activated adenoid cystic cancer. AL101 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving AL101 before surgery may help to control...

What is the current status of trial NCT04973683?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 14 participants. The study started on 2021-09-30. Estimated completion is 2025-12-15.

What conditions does trial NCT04973683 study?

This clinical trial studies the following conditions: Adenoid Cystic Carcinoma, Metastatic Adenoid Cystic Carcinoma.

What interventions are being tested in trial NCT04973683?

The interventions under investigation include: Therapeutic Conventional Surgery (PROCEDURE), AL101 (DRUG).

Who is sponsoring clinical trial NCT04973683?

This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04973683 being conducted?

This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.