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NCT04954157 · ClinicalTrials.gov registry record · NA
Studies to Determine Whether Oxygen Sensing is Impaired in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infected Patients
A NA study, sponsored by University of Chicago.
- Completed
- Registry status
- NA
- Development phase
- 80
- Enrollment target
NCT04954157: Completed NA study, sponsored by University of Chicago.
NCT04954157 is a NA study that has completed, run by University of Chicago. The registered enrollment target is 80 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (94% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04954157, a NA study, has completed, sponsored by University of Chicago.
- COMPLETED
- Registry status
- NA
- Development phase
- 80 participants
- Enrollment target
Study Summary
The two-part phases will each have a unique patient population, The goal in this application is to see if that carotid bodies are "offline" is correct and to determine whether a cohort of SARS-Cov-2 patients can be identified who fit this profile and would be suitable for drug treatment. The testing will require one group of subjects to hold their breaths for a short period while the investigators monitor vital signs and blood O2 levels. A second group of "healthier" COVID subjects will be asked perform a walk-test inside their rooms for six minutes while vital signs are monitored as well as blood O2 levels. If the subjects are in the healthy control group, they will perform the walk test in a designated hallway at the medical center also while there vitals are being monitored. The goal, using a mild stimulus, is to determine whether respiration increases if blood O2 saturation is decreased. If it does not, that would indicate a failure of the carotid body oxygen sensing system.
Primary Outcome
This will determined by asking subjects to take a regular breath, and exhale, hold it until you have to take another breath or until 1) you cannot hold it anymore; 2) up to 60 sec; 3) your O2 saturation falls to 85% or lower, 4) you feel dizzy, or 5) heart rate change \> 30 % of the baseline (pre breath holding heart rate.
Interventions
- DIAGNOSTIC_TEST Phase-1: Breath Holding Test
- DIAGNOSTIC_TEST Phase 2: 6-Minute Walk Test (6MWT)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 80 participants |
| Start Date | 2020-06-29 |
| Est. Completion | 2022-04-21 |
| Phase | NA |
What the finished NCT04954157 record still lists
NCT04954157 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 80 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (94% lower).
The record links to 0 conditions, and to 2 interventions - of which Phase-1: Breath Holding Test is the first listed.
NCT04954157 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04954157 about?
NCT04954157 is a clinical study titled "Studies to Determine Whether Oxygen Sensing is Impaired in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infected Patients". The two-part phases will each have a unique patient population, The goal in this application is to see if that carotid bodies are "offline" is correct and to determine whether a cohort of SARS-Cov-2 patients can be identified who fit this profile and would be suitable for drug treatment. The testin...
What is the current status of trial NCT04954157?
This trial is currently completed. It is a NA study. The enrollment target is 80 participants. The study started on 2020-06-29. Estimated completion is 2022-04-21.
What interventions are being tested in trial NCT04954157?
The interventions under investigation include: Phase-1: Breath Holding Test (DIAGNOSTIC_TEST), Phase 2: 6-Minute Walk Test (6MWT) (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT04954157?
This trial is sponsored by University of Chicago, which has 796 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04954157's enrollment target sits among peer trials
80 994th of 2000 higher than 941 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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