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NCT04925492 · ClinicalTrials.gov registry record · Phase 1
PET Imaging of Vaso-Occlusive Crisis (VOC) in SCD
A Phase 1 study of Sickle Cell Disease, sponsored by Enrico Novelli.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT04925492: Recruiting Phase 1 study of Sickle Cell Disease, sponsored by Enrico Novelli.
NCT04925492 is a Phase 1 study of Sickle Cell Disease that is actively recruiting participants, run by Enrico Novelli. The registered enrollment target is 20 participants, below the 293-participant average among 213 other Sickle Cell Disease trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04925492, a Phase 1 study of Sickle Cell Disease, is actively recruiting participants, sponsored by Enrico Novelli.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to find objective biomarkers of vaso-occlusion (blood vessel blockage) in people with SCD. Using information from earlier studies and work being done, researchers have developed a strategy to image VOC, using positron emission tomography (PET). The ability to see and measure VOC in SCD patients can help patient care, by showing when and how a VOC is occurring or going to occur. Studying this method will also help in future drug research, as it will allow researchers to deliver promising new medications that target hyper-adhesion and sickling in people with SCD.
Primary Outcome
Intensity of PET tracer uptake in VOC will be measured and compared to uptake at baseline in predefined regions of interest and over the whole body
Conditions Studied
Interventions
- RADIATION Positron Emission Tomography
- DRUG Cu-64]-LLP2A
Study Locations (1)
Pennsylvania
- UPMC - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2022-11-11 |
| Est. Completion | 2027-12-31 |
| Phase | Phase 1 |
What NCT04925492 shows while recruiting
NCT04925492 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 293-participant average among 213 other Sickle Cell Disease trials with a reported enrollment target (93% lower).
The record links to 1 condition, with Sickle Cell Disease appearing as the primary indexed condition, and to 2 interventions - of which Positron Emission Tomography is the first listed.
NCT04925492 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT04925492 about?
NCT04925492 is a clinical study titled "PET Imaging of Vaso-Occlusive Crisis (VOC) in SCD". The purpose of this study is to find objective biomarkers of vaso-occlusion (blood vessel blockage) in people with SCD. Using information from earlier studies and work being done, researchers have developed a strategy to image VOC, using positron emission tomography (PET). The ability to see and me...
What is the current status of trial NCT04925492?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2022-11-11. Estimated completion is 2027-12-31.
What conditions does trial NCT04925492 study?
This clinical trial studies the following conditions: Sickle Cell Disease.
What interventions are being tested in trial NCT04925492?
The interventions under investigation include: Positron Emission Tomography (RADIATION), Cu-64]-LLP2A (DRUG).
Who is sponsoring clinical trial NCT04925492?
This trial is sponsored by Enrico Novelli, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04925492 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT04925492's enrollment target sits among peer trials
20 172nd of 213 higher than 33 of 213 other Sickle Cell Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Sickle Cell Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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