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NCT07431398 · ClinicalTrials.gov registry record · Phase 1
Single-dose Pharmacokinetics of Pociredir in Participants With Sickle Cell Disease
A Phase 1 study of Sickle Cell Disease, sponsored by Fulcrum Therapeutics.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 24
- Enrollment target
- 6
- Study locations
NCT07431398: Recruiting Phase 1 study of Sickle Cell Disease, sponsored by Fulcrum Therapeutics.
NCT07431398 is a Phase 1 study of Sickle Cell Disease that is actively recruiting participants, run by Fulcrum Therapeutics. The registered enrollment target is 24 participants, below the 293-participant average among 213 other Sickle Cell Disease trials with a reported enrollment target (92% lower). The trial reports 6 study locations across 4 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07431398, a Phase 1 study of Sickle Cell Disease, is actively recruiting participants, sponsored by Fulcrum Therapeutics.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 24 participants
- Enrollment target
- 6
- Study locations
Study Summary
This clinical trial is a study to evaluate the pharmacokinetics of the tablet formulation Pociredir in fasted and fed state participants with Sickle Cell Disease (SCD).
Conditions Studied
Interventions
- DRUG Pociredir
Study Locations (6)
Florida
- Advanced Pharma - Miami - Miami
- Omega Research Group - Orlando
Texas
- University of Texas Health Science Center Houston - Houston
- Worldwide Clinical Trials - San Antonio
Georgia
- Sonar Clinical Research - Riverdale
Ohio
- Neuro-Behavioral Clinical Research - North Canton
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 24 participants |
| Start Date | 2025-12-13 |
| Est. Completion | 2026-04 |
| Phase | Phase 1 |
What NCT07431398 shows while recruiting
NCT07431398 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 24 participants, a relatively small participant target, below the 293-participant average among 213 other Sickle Cell Disease trials with a reported enrollment target (92% lower).
The record links to 1 condition, with Sickle Cell Disease appearing as the primary indexed condition, and to 1 intervention - of which Pociredir is the first listed.
NCT07431398 lists 6 locations in 4 states (Florida, Texas, Georgia).
Frequently Asked Questions
What is clinical trial NCT07431398 about?
NCT07431398 is a clinical study titled "Single-dose Pharmacokinetics of Pociredir in Participants With Sickle Cell Disease". This clinical trial is a study to evaluate the pharmacokinetics of the tablet formulation Pociredir in fasted and fed state participants with Sickle Cell Disease (SCD).
What is the current status of trial NCT07431398?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 24 participants. The study started on 2025-12-13. Estimated completion is 2026-04.
What conditions does trial NCT07431398 study?
This clinical trial studies the following conditions: Sickle Cell Disease.
What interventions are being tested in trial NCT07431398?
The interventions under investigation include: Pociredir (DRUG).
Who is sponsoring clinical trial NCT07431398?
This trial is sponsored by Fulcrum Therapeutics, which has 8 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07431398 being conducted?
This trial has 6 study locations across Florida, Georgia, Ohio, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Sickle Cell Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07431398's enrollment target sits among peer trials
24 160th of 213 higher than 49 of 213 other Sickle Cell Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Sickle Cell Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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