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NCT04891640 · ClinicalTrials.gov registry record · NA
Biologic Abatement and Capturing Kids' Outcomes and Flare Frequency in Juvenile Spondyloarthritis
A NA study of Juvenile Spondyloarthritis, sponsored by Children's Hospital of Philadelphia.
- Active
- Registry status
- NA
- Development phase
- 164
- Enrollment target
- 20
- Study locations
NCT04891640 is a NA study of Juvenile Spondyloarthritis that is active but no longer recruiting, run by Children's Hospital of Philadelphia. The registered enrollment target is 164 participants. The trial reports 20 study locations across 17 states.
The verdict
NCT04891640, a NA study of Juvenile Spondyloarthritis, is active but no longer recruiting, sponsored by Children's Hospital of Philadelphia.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 164 participants
- Enrollment target
- 20
- Study locations
Study Summary
This randomized pragmatic trial will generate knowledge about strategies used to de-escalate tumor necrosis factor inhibitor (TNFi) therapy in patients with juvenile spondyloarthritis with sustained inactive disease and are treated at one of the 29 participating pediatric healthcare systems. This open label study will be conducted in the setting of routine clinical care and will compare the risk and timing of flare (Aim 1) and patients' lived experiences (Aim 2) across three arms.
Conditions Studied
Interventions
- OTHER Standard TNFi Therapy
- OTHER TNFi fixed longer dosing intervals
- OTHER Stop TNFi treatment
Study Locations (20)
California
- Children's Hospital Los Angeles - Los Angeles
- Stanford University - Palo Alto
Missouri
- Children's Mercy Hospital - Kansas City
- St. Louis Children's Hospital - St Louis
New York
- Hospital for Special Surgery - New York
- Cohen Children's Medical Center - Queens
Alabama
- University of Alabama at Birmingham - Birmingham
Arizona
- Phoenix Children's - Phoenix
Colorado
- Children's Hospital of Colorado - Aurora
Delaware
- Nemours Children's Hospital - Wilmington
District of Columbia
- Children's National Health System - Washington D.C.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 164 participants |
| Start Date | 2021-11-11 |
| Est. Completion | 2026-07-01 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04891640
The ClinicalTrials.gov registry entry for NCT04891640 describes a study currently listed as active not recruiting, categorized as NA. The registered enrollment target is 164 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Children's Hospital of Philadelphia, which has 431 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Juvenile Spondyloarthritis appearing as the primary indexed condition, and to 3 interventions - of which Standard TNFi Therapy is the first listed.
NCT04891640 reports 20 study locations spanning 17 distinct geographic areas - top geographies include California, Missouri, New York.
Frequently Asked Questions
What is clinical trial NCT04891640 about?
NCT04891640 is a clinical study titled "Biologic Abatement and Capturing Kids' Outcomes and Flare Frequency in Juvenile Spondyloarthritis". This randomized pragmatic trial will generate knowledge about strategies used to de-escalate tumor necrosis factor inhibitor (TNFi) therapy in patients with juvenile spondyloarthritis with sustained inactive disease and are treated at one of the 29 participating pediatric healthcare systems. This op...
What is the current status of trial NCT04891640?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 164 participants. The study started on 2021-11-11. Estimated completion is 2026-07-01.
What conditions does trial NCT04891640 study?
This clinical trial studies the following conditions: Juvenile Spondyloarthritis.
What interventions are being tested in trial NCT04891640?
The interventions under investigation include: Standard TNFi Therapy (OTHER), TNFi fixed longer dosing intervals (OTHER), Stop TNFi treatment (OTHER).
Who is sponsoring clinical trial NCT04891640?
This trial is sponsored by Children's Hospital of Philadelphia, which has 431 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04891640 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Colorado, Delaware. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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