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NCT04782076 · ClinicalTrials.gov registry record · Phase 1
A Drug Drug Interaction (DDI) Study of Selpercatinib and Dabigatran in Healthy Participants
A Phase 1 study, sponsored by Loxo Oncology.
- Completed
- Registry status
- Phase 1
- Development phase
- 36
- Enrollment target
NCT04782076: Completed Phase 1 study, sponsored by Loxo Oncology.
NCT04782076 is a Phase 1 study that has completed, run by Loxo Oncology. The registered enrollment target is 36 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (40% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04782076, a Phase 1 study, has completed, sponsored by Loxo Oncology.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 36 participants
- Enrollment target
Study Summary
The main purpose of this study is to determine the effect of selpercatinib on the levels of dabigatran in the blood stream and how long it takes the body to remove dabigatran. This study will also look at how safe and well-tolerated of dabigatran when administered in combination with selpercatinib in healthy participants. This study will last approximately 22 to 25 days.
Primary Outcome
PK: Cmax of Dabigatran
Interventions
- DRUG Selpercatinib
- DRUG Dabigatran
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 36 participants |
| Start Date | 2021-03-05 |
| Est. Completion | 2021-05-17 |
| Phase | Phase 1 |
What the finished NCT04782076 record still lists
NCT04782076 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 36 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (40% lower).
The record links to 0 conditions, and to 2 interventions - of which Selpercatinib is the first listed.
NCT04782076 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04782076 about?
NCT04782076 is a clinical study titled "A Drug Drug Interaction (DDI) Study of Selpercatinib and Dabigatran in Healthy Participants". The main purpose of this study is to determine the effect of selpercatinib on the levels of dabigatran in the blood stream and how long it takes the body to remove dabigatran. This study will also look at how safe and well-tolerated of dabigatran when administered in combination with selpercatinib i...
What is the current status of trial NCT04782076?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 36 participants. The study started on 2021-03-05. Estimated completion is 2021-05-17.
What interventions are being tested in trial NCT04782076?
The interventions under investigation include: Selpercatinib (DRUG), Dabigatran (DRUG).
Who is sponsoring clinical trial NCT04782076?
This trial is sponsored by Loxo Oncology, which has 14 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04782076's enrollment target sits among peer trials
36 1210th of 2000 higher than 743 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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