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ACTIVE NOT RECRUITING Phase 2

131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma

NCT04743661 · View on ClinicalTrials.gov ↗

Study Summary

A Phase 2 study investigating the addition of cRIT 131I-omburtamab to irinotecan, temozolomide, and bevacizumab for patients with recurrent medulloblastoma. A feasibility cohort is included to assess the feasibility of incorporating cRIT 131I-omburtamab for patients with recurrent ependymoma. Direct intraventricular delivery of radiolabeled tumor-specific antibodies may aid in both the detection and treatment of recurrent disease for these highly specific pediatric patients with recurrent tumors.

Interventions

  • DRUG Bevacizumab
  • DRUG Temozolomide
  • DRUG Irinotecan
  • DRUG Omburtamab I-131
  • DRUG Liothyronine

Study Locations (3)

California

  • Children's Hospital Los Angeles — Los Angeles

New York

  • Memorial Sloan Kettering Cancer Center — New York

Ohio

  • Cincinnati Children's Hospital Medical Center — Cincinnati

Trial Details

FieldValue
Enrollment Target 62 participants
Start Date 2022-04-04
Est. Completion 2027-09-30
Phase Phase 2

Sponsor

Pediatric Brain Tumor Consortium

8 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04743661

The ClinicalTrials.gov registry entry for NCT04743661 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 62 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Pediatric Brain Tumor Consortium, which has 8 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Recurrent Medulloblastoma appearing as the primary indexed condition, and to 5 interventions — of which Bevacizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04743661 reports 3 study locations spanning 3 distinct geographic areas — top geographies include California, New York, Ohio. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04743661 about?

NCT04743661 is a clinical study titled "131I-Omburtamab, in Recurrent Medulloblastoma and Ependymoma". A Phase 2 study investigating the addition of cRIT 131I-omburtamab to irinotecan, temozolomide, and bevacizumab for patients with recurrent medulloblastoma. A feasibility cohort is included to assess the feasibility of incorporating cRIT 131I-omburtamab for patients with recurrent ependymoma. Direc...

What is the current status of trial NCT04743661?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 62 participants. The study started on 2022-04-04. Estimated completion is 2027-09-30.

What conditions does trial NCT04743661 study?

This clinical trial studies the following conditions: Recurrent Medulloblastoma, Recurrent Ependymoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04743661?

The interventions under investigation include: Bevacizumab (DRUG), Temozolomide (DRUG), Irinotecan (DRUG), Omburtamab I-131 (DRUG), Liothyronine (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04743661?

This trial is sponsored by Pediatric Brain Tumor Consortium, which has 8 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04743661 being conducted?

This trial has 3 study locations across California, New York, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial