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NCT04732000 · ClinicalTrials.gov registry record · Phase 2
Oxidative Stress and Surgical Recovery
A Phase 2 study of Pain, Postoperative and Surgical Recovery, sponsored by Stanford University.
- Completed
- Registry status
- Phase 2
- Development phase
- 30
- Enrollment target
- 1
- Study location
NCT04732000 is a Phase 2 study of Pain, Postoperative and Surgical Recovery that has completed, run by Stanford University. The registered enrollment target is 30 participants, below the 272-participant average among 108 other Pain, Postoperative trials with a reported enrollment target (89% lower). The trial reports 1 study location across 1 state.
The verdict
NCT04732000, a Phase 2 study of Pain, Postoperative and Surgical Recovery, has completed, sponsored by Stanford University.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 30 participants
- Enrollment target
- 1
- Study location
Study Summary
Chronic pain, functional impairment and slow rates of recovery are key issues for patients after surgery and trauma. No preventative strategy in current use unequivocally modifies these rates, and few novel approaches have been tested. Furthermore, persistent postsurgical pain is a major route to chronic opioid use, opioid use disorder and, regrettably, opioid overdose. Most strategies designed to limit chronic pain or enhance functional recovery after surgery are directed at modulating peripheral and central nervous system activity and do not strongly modify the underlying tissue pathophysiology or fundamental systemic responses. Strategies limiting oxidative stress in the perioperative period, on the other hand, might limit tissue damage, organ dysfunction and immune system activation. N-acetyl cysteine (NAC) is an antioxidant well-studied in the perioperative period; it is very safe, relatively inexpensive and widely available. The central hypothesis is, therefore, that perioperative administration of NAC will reduce perioperative oxidative stress, limit immune system activation and improve key indices of surgical recovery. Although the planned work will not comprehensively address this hypothesis, it will identify the most useful tools and help the researchers estimate the required sample sizes for more definitive externally funded efforts.
Conditions Studied
Interventions
- OTHER Normal Saline
- DRUG N-acetyl cysteine
Study Locations (1)
California
- Stanford University School of Medicine - Stanford
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2021-07-01 |
| Est. Completion | 2023-03-01 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04732000
The ClinicalTrials.gov registry entry for NCT04732000 describes a study currently listed as completed, categorized as Phase 2. The registered enrollment target is 30 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 272-participant average among 108 other Pain, Postoperative trials with a reported enrollment target (89% lower). The listed sponsor is Stanford University, which has 1,744 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Pain, Postoperative appearing as the primary indexed condition, and to 2 interventions - of which Normal Saline is the first listed.
NCT04732000 reports 1 study location spanning 1 distinct geographic area - top geographies include California.
Frequently Asked Questions
What is clinical trial NCT04732000 about?
NCT04732000 is a clinical study titled "Oxidative Stress and Surgical Recovery". Chronic pain, functional impairment and slow rates of recovery are key issues for patients after surgery and trauma. No preventative strategy in current use unequivocally modifies these rates, and few novel approaches have been tested. Furthermore, persistent postsurgical pain is a major route to ch...
What is the current status of trial NCT04732000?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 30 participants. The study started on 2021-07-01. Estimated completion is 2023-03-01.
What conditions does trial NCT04732000 study?
This clinical trial studies the following conditions: Pain, Postoperative, Surgical Recovery.
What interventions are being tested in trial NCT04732000?
The interventions under investigation include: Normal Saline (OTHER), N-acetyl cysteine (DRUG).
Who is sponsoring clinical trial NCT04732000?
This trial is sponsored by Stanford University, which has 1,744 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04732000 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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