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NCT04730557 · ClinicalTrials.gov registry record · NA
Reducing Obesity and Cartilage Compression in Knees
A NA study, sponsored by Duke University.
- Completed
- Registry status
- NA
- Development phase
- 88
- Enrollment target
NCT04730557: Completed NA study, sponsored by Duke University.
NCT04730557 is a NA study that has completed, run by Duke University. The registered enrollment target is 88 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (94% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04730557, a NA study, has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- NA
- Development phase
- 88 participants
- Enrollment target
Study Summary
OA is a degenerative joint disease that involves the degradation of articular cartilage and underlying subchondral bone. Obesity is identified as a critical and potentially modifiable risk factor for the development and progression of OA. The first objective of the study is to determine the effects of obesity on cartilage composition and function. The second objective of the study is to determine whether weight loss restores cartilage composition and function. Study activities would require getting MR Imaging, evaluation of joint loading using gait analysis techniques, cartilage strain measurement, and participating in weight loss intervention. The study will target a population age group between 18 and 45 years with a BMI greater than or equal to 29. Data analyses will be blinded to reduce potential bias. All subjects participating in this study will be informed of the risks involved and sign an IRB-approved consent form.
Primary Outcome
We will use MRI to detect change in cartilage strain/thickness at 3 and 6 months
Interventions
- BEHAVIORAL Weight Loss
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 88 participants |
| Start Date | 2020-06-05 |
| Est. Completion | 2024-05-17 |
| Phase | NA |
What the finished NCT04730557 record still lists
NCT04730557 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 88 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (94% lower).
The record links to 0 conditions, and to 1 intervention - of which Weight Loss is the first listed.
NCT04730557 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT04730557 about?
NCT04730557 is a clinical study titled "Reducing Obesity and Cartilage Compression in Knees". OA is a degenerative joint disease that involves the degradation of articular cartilage and underlying subchondral bone. Obesity is identified as a critical and potentially modifiable risk factor for the development and progression of OA. The first objective of the study is to determine the effects ...
What is the current status of trial NCT04730557?
This trial is currently completed. It is a NA study. The enrollment target is 88 participants. The study started on 2020-06-05. Estimated completion is 2024-05-17.
What interventions are being tested in trial NCT04730557?
The interventions under investigation include: Weight Loss (BEHAVIORAL).
Who is sponsoring clinical trial NCT04730557?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT04730557's enrollment target sits among peer trials
88 972nd of 2000 higher than 1,027 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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