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NCT04643431 · ClinicalTrials.gov registry record · Phase 4
Risk Assessment of Carotid Plaques Using 3D Contrast-Enhanced Ultrasound
A Phase 4 study of Carotid Atherosclerosis, sponsored by Thomas Jefferson University.
- Active
- Registry status
- Phase 4
- Development phase
- 20
- Enrollment target
- 1
- Study location
NCT04643431: Active Phase 4 study of Carotid Atherosclerosis, sponsored by Thomas Jefferson University.
NCT04643431 is a Phase 4 study of Carotid Atherosclerosis that is active but no longer recruiting, run by Thomas Jefferson University. The registered enrollment target is 20 participants, below the 169-participant average among 5 other Carotid Atherosclerosis trials with a reported enrollment target (88% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04643431, a Phase 4 study of Carotid Atherosclerosis, is active but no longer recruiting, sponsored by Thomas Jefferson University.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 4
- Development phase
- 20 participants
- Enrollment target
- 1
- Study location
Study Summary
This is an open-label, non-randomized study conducted at Thomas Jefferson University comparing pressure-gradient estimates (obtained between a carotid plaque and the carotid artery) to imaging and histology markers of plaque vulnerability. There is an inverse relationship between the subharmonic signal magnitude from contrast-enhanced ultrasound microbubbles and ambient pressure. This pressure estimation technique (referred as SHAPE) will be used to estimate the pressure gradient across the carotid plaque cap noninvasively in vivo.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Perflutren
Study Locations (1)
Pennsylvania
- Thomas jefferson University - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2020-12-01 |
| Est. Completion | 2025-12-31 |
| Phase | Phase 4 |
What the registry record for NCT04643431 still lists
NCT04643431 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 20 participants, a relatively small participant target, below the 169-participant average among 5 other Carotid Atherosclerosis trials with a reported enrollment target (88% lower).
The record links to 1 condition, with Carotid Atherosclerosis appearing as the primary indexed condition, and to 1 intervention - of which Perflutren is the first listed.
NCT04643431 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT04643431 about?
NCT04643431 is a clinical study titled "Risk Assessment of Carotid Plaques Using 3D Contrast-Enhanced Ultrasound". This is an open-label, non-randomized study conducted at Thomas Jefferson University comparing pressure-gradient estimates (obtained between a carotid plaque and the carotid artery) to imaging and histology markers of plaque vulnerability. There is an inverse relationship between the subharmonic sig...
What is the current status of trial NCT04643431?
This trial is currently active not recruiting. It is a Phase 4 study. The enrollment target is 20 participants. The study started on 2020-12-01. Estimated completion is 2025-12-31.
What conditions does trial NCT04643431 study?
This clinical trial studies the following conditions: Carotid Atherosclerosis.
What interventions are being tested in trial NCT04643431?
The interventions under investigation include: Perflutren (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT04643431?
This trial is sponsored by Thomas Jefferson University, which has 292 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04643431 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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