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NCT00001589 · ClinicalTrials.gov registry record
Comparison of Asymptomatic Carotid Atherosclerosis Between Frequent and Infrequent Blood Donors
A clinical trial of Myocardial Infarction and Carotid Atherosclerosis, sponsored by National Institutes of Health Clinical Center (CC).
- Completed
- Registry status
- 120
- Enrollment target
- 1
- Study location
NCT00001589: Completed study of Myocardial Infarction and Carotid Atherosclerosis, sponsored by National Institutes of Health Clinical Center (CC).
NCT00001589 is a study of Myocardial Infarction and Carotid Atherosclerosis that has completed, run by National Institutes of Health Clinical Center (CC). The registered enrollment target is 120 participants, below the 4,680-participant average among 64 other Myocardial Infarction trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00001589, a study of Myocardial Infarction and Carotid Atherosclerosis, has completed, sponsored by National Institutes of Health Clinical Center (CC).
- COMPLETED
- Registry status
- 120 participants
- Enrollment target
- 1
- Study location
Study Summary
Iron has been proposed to contribute to atherogenesis in humans by facilitating the oxidation of lipoproteins. This observational study will evaluate the association between frequency of blood donation - expected to be associated with relatively reduced body iron stores in frequent donors - and carotid atherosclerosis. The primary outcome variable will be whether the presence and extent of asymptomatic carotid atherosclerosis as measured by ultrasound is greater in infrequent (less than or equal to 1 donations/year greater than or equal to 5 years) vs. frequent (greater than or equal to 4 donations/year greater than or equal to 5 years) blood donors. Body iron stores, lipid and hemostatic parameters, nitric oxide formation, inflammatory parameters, and markers of vascular oxidative stress will be analyzed as secondary outcome measures. Laboratory analysis and ultrasound testing will be performed blinded to the patient's phlebotomy and iron status. Sixty frequent (n=40 males greater than 40 y/o, n=20 females greater than 50 y/o) and 60 infrequent (n=40 males greater than 40 y/o, n=20 females greater than 50 y/o) blood donors will be recruited for this study from the Department of Transfusion Medicine, W. G. Magnuson Clinical Center. All donors will be assessed for study eligibility and cardiovascular risks during the screening visit. The presence of atherosclerotic lesions by carotid ultrasound and secondary outcome parameters will be assessed during a second visit.
Conditions Studied
Study Locations (1)
Maryland
- Warren G. Magnuson Clinical Center (CC) - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 1997-04 |
| Est. Completion | 2002-05 |
What the finished NCT00001589 record still lists
NCT00001589 is an observational study that tracks outcomes without assigning an intervention. The registered 120 participants enrollment target is mid-sized for trials with a published cap, below the 4,680-participant average among 64 other Myocardial Infarction trials with a reported enrollment target (97% lower).
The record links to 2 conditions, with Myocardial Infarction appearing as the primary indexed condition, and to 0 interventions.
NCT00001589 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT00001589 about?
NCT00001589 is a clinical study titled "Comparison of Asymptomatic Carotid Atherosclerosis Between Frequent and Infrequent Blood Donors". Iron has been proposed to contribute to atherogenesis in humans by facilitating the oxidation of lipoproteins. This observational study will evaluate the association between frequency of blood donation - expected to be associated with relatively reduced body iron stores in frequent donors - and caro...
What is the current status of trial NCT00001589?
This trial is currently completed. The enrollment target is 120 participants. The study started on 1997-04. Estimated completion is 2002-05.
What conditions does trial NCT00001589 study?
This clinical trial studies the following conditions: Myocardial Infarction, Carotid Atherosclerosis.
Who is sponsoring clinical trial NCT00001589?
This trial is sponsored by National Institutes of Health Clinical Center (CC), which has 338 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00001589 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT00001589's enrollment target sits among peer trials
120 47th of 64 higher than 17 of 64 other Myocardial Infarction trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Myocardial Infarction trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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